| Literature DB >> 1978783 |
G C Wishart1, J A Plumb, J J Going, A M McNicol, C S McArdle, T Tsuruo, S B Kaye.
Abstract
We have investigated P-glycoprotein (P-gp) expression in samples of primary breast cancer from 29 patients before therapy. We employed immunohistochemical techniques using two monoclonal antibodies (C219 and MRK16) and an indirect alkaline phosphatase method. Heterogeneous expression in epithelial cells was detected with both C219 (21 of 29) and MRK16 (16 of 29). A surprising finding was P-glycoprotein expression in stromal cells with both C219 (26 of 29) and MRK16 (12 of 29). Our results suggest that significant levels of P-glycoprotein expression may be present in breast cancer before exposure to drugs associated with multidrug resistance.Entities:
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Year: 1990 PMID： 1978783 PMCID： PMC1971543 DOI： 10.1038/bjc.1990.373
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640