Literature DB >> 1978561

A new DNA marker (D10S94) very tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus.

P J Goodfellow1, S Myers, L L Anderson, A R Brooks-Wilson, N E Simpson.   

Abstract

Combined somatic cell hybrid and linkage studies between D10S94 and five pericentromeric loci (FNRB, D10Z1, MEN2A, RBP3, and D10S15) have localized the new DNA sequence pcl1/A1S-6-c23 at D10S94 to 10q11.2. No recombinants were observed between D10S94 and D10Z1 or MEN2A. D10S94 maps in proximal 10q11.2 very near to MEN2A. There are three possible orders for the six loci that we investigated from the centromeric region of chromosome 10. At present the genetic data do not allow us to order MEN2A with respect to D10Z1 and D10S94. The three possible orders are FNRB-D10Z1-D10S94-MEN2A-RBP3-D10S15, FNRB-D10Z1-MEN2A-D10S94-RBP3-D10S15, and FNRB-MEN2A-D10Z1-D10S94-RBP3-D10S15. In view of the fact that no recombinants between D10S94 and MEN2A or between D10S94 and D10Z1 were observed, the combined haplotypes formed from RFLPs and D10Z1 and D10S94 will increase the informativeness and accuracy of genotype prediction for at-risk members of the families having the MEN 2A syndrome, particularly when the affected parent is female. The localization of D10S94 with respect to MEN2A will prove valuable in experiments directed toward cloning the MEN2A locus.

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Year:  1990        PMID： 1978561      PMCID： PMC1683904     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  21 in total

1.  An extended genetic linkage map of markers for human chromosome 10.

Authors:  Y Nakamura; M Lathrop; T Bragg; M Leppert; P O'Connell; C Jones; J M Lalouel; R White
Journal:  Genomics       Date:  1988-11       Impact factor: 5.736

2.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

3.  Chromosome-specific alpha satellite DNA: isolation and mapping of a polymorphic alphoid repeat from human chromosome 10.

Authors:  P Devilee; T Kievits; J S Waye; P L Pearson; H F Willard
Journal:  Genomics       Date:  1988-07       Impact factor: 5.736

4.  A primary genetic map of markers of human chromosome 10.

Authors:  M Lathrop; Y Nakamura; P Cartwright; P O'Connell; M Leppert; C Jones; H Tateishi; T Bragg; J M Lalouel; R White
Journal:  Genomics       Date:  1988-02       Impact factor: 5.736

5.  The clinical and screening age-at-onset distribution for the MEN-2 syndrome.

Authors:  D F Easton; M A Ponder; T Cummings; R F Gagel; H H Hansen; S Reichlin; A H Tashjian; M Telenius-Berg; B A Ponder
Journal:  Am J Hum Genet       Date:  1989-02       Impact factor: 11.025

6.  Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage.

Authors:  N E Simpson; K K Kidd; P J Goodfellow; H McDermid; S Myers; J R Kidd; C E Jackson; A M Duncan; L A Farrer; K Brasch
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962

7.  A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10.

Authors:  C G Mathew; K S Chin; D F Easton; K Thorpe; C Carter; G I Liou; S L Fong; C D Bridges; H Haak; A C Kruseman
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962

8.  The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience.

Authors:  R F Gagel; A H Tashjian; T Cummings; N Papathanasopoulos; M M Kaplan; R A DeLellis; H J Wolfe; S Reichlin
Journal:  N Engl J Med       Date:  1988-02-25       Impact factor: 91.245

9.  Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization.

Authors:  G I Liou; S L Fong; J Gosden; P van Tuinen; D H Ledbetter; S Christie; D Rout; S Bhattacharya; R G Cook; Y Li
Journal:  Somat Cell Mol Genet       Date:  1987-07

10.  Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2.

Authors:  P J Goodfellow; H A Nevanlinna; P Gorman; D Sheer; G Lam; P N Goodfellow
Journal:  Ann Hum Genet       Date:  1989-01       Impact factor: 1.670
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  6 in total

1.  Construction of radiation-reduced hybrids and their use in mapping of microclones from chromosome 10p11.2-q11.2.

Authors:  S Fujita; E Shin; T Nakamura; H Kurahashi; Y Kaneda; K Tanaka; T Mori; S Takai; I Nishisho
Journal:  Jpn J Hum Genet       Date:  1993-12

2.  Genetic analysis of 24 French families with multiple endocrine neoplasia type 2A.

Authors:  S A Narod; M F Lavoué; K Morgan; C Calmettes; H Sobol; P J Goodfellow; G M Lenoir
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

3.  The clinical implications of a positive calcitonin test for C-cell hyperplasia in genetically unaffected members of an MEN2A kindred.

Authors:  R M Landsvater; A G Rombouts; G J te Meerman; J M Schillhorn-van Veen; M J Berends; R A Geerdink; A Struyvenberg; C H Buys; C J Lips
Journal:  Am J Hum Genet       Date:  1993-02       Impact factor: 11.025

4.  A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus.

Authors:  J B Lichter; J Wu; A R Brooks-Wilson; M Difillipantonio; S Brewster; D C Ward; P J Goodfellow; K K Kidd
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132

5.  A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.

Authors:  T C Lairmore; S Dou; J R Howe; D Chi; K Carlson; R Veile; S K Mishra; S A Wells; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

6.  Improved predictive test for MEN2, using flanking dinucleotide repeats and RFLPs.

Authors:  J R Howe; T C Lairmore; S K Mishra; S Dou; R Veile; S A Wells; H Donis-Keller
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025
  6 in total

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