Literature DB >> 19784453

Governance of dual-use research: an ethical dilemma.

Michael J Selgelid1.   

Abstract

Scenarios where the results of well-intentioned scientific research can be used for both good and harmful purposes give rise to what is now widely known as the 'dual-use dilemma'. There has been growing debate about the dual-use nature of life science research with implications for making biological weapons. This paper reviews several controversial publications that have been the focus of debates about dual-use life science research and critically examines relevant policy developments, particularly in the United States of America. Though the dual-use dilemma is inherently ethical in nature, the majority of debates about dual-use research have primarily involved science and security experts rather than ethicists. It is important that there is more ethical input into debates about the governance of dual-use research.

Mesh:

Year:  2009        PMID: 19784453      PMCID: PMC2739909          DOI: 10.2471/blt.08.051383

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN: 0042-9686            Impact factor:   9.408


  9 in total

1.  Uncensored exchange of scientific results.

Authors:  Ronald Atlas; Philip Campbell; Nicholas R Cozzarelli; Greg Curfman; Lynn Enquist; Gerald Fink; Annette Flanagin; Jacqueline Fletcher; Elizabeth George; Gordon Hammes; David Heyman; Thomas Inglesby; Samuel Kaplan; Donald Kennedy; Judith Krug; Rachel E Levinson; Emilie Marcus; Henry Metzger; Stephen S Morse; Alison O'Brien; Andrew Onderdonk; George Poste; Beatrice Renault; Robert Rich; Ariella Rosengard; Steven Salzberg; Steven Salzburg; Mary Scanlan; Thomas Shenk; Herbert Tabor; Harold Varmus; Eckard Wimmer; Keith Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-15       Impact factor: 11.205

2.  Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Authors:  Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Journal:  Science       Date:  2002-07-11       Impact factor: 47.728

3.  Better never than late.

Authors:  Donald Kennedy
Journal:  Science       Date:  2005-10-14       Impact factor: 47.728

4.  Guidelines to prevent malevolent use of biomedical research.

Authors:  Shane K Green; Sara Taub; Karine Morin; Daniel Higginson
Journal:  Camb Q Healthc Ethics       Date:  2006       Impact factor: 1.284

5.  A tale of two studies; ethics, bioterrorism, and the censorship of science.

Authors:  Michael J Selgelid
Journal:  Hastings Cent Rep       Date:  2007 May-Jun       Impact factor: 2.683

6.  Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

Authors:  R J Jackson; A J Ramsay; C D Christensen; S Beaton; D F Hall; I A Ramshaw
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

7.  Variola virus immune evasion design: expression of a highly efficient inhibitor of human complement.

Authors:  Ariella M Rosengard; Yu Liu; Zhiping Nie; Robert Jimenez
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

8.  Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

Authors:  Terrence M Tumpey; Christopher F Basler; Patricia V Aguilar; Hui Zeng; Alicia Solórzano; David E Swayne; Nancy J Cox; Jacqueline M Katz; Jeffery K Taubenberger; Peter Palese; Adolfo García-Sastre
Journal:  Science       Date:  2005-10-07       Impact factor: 47.728

9.  Ethical and philosophical consideration of the dual-use dilemma in the biological sciences.

Authors:  Seumas Miller; Michael J Selgelid
Journal:  Sci Eng Ethics       Date:  2007-12-01       Impact factor: 3.525

  9 in total
  11 in total

Review 1.  Biosecurity and the review and publication of dual-use research of concern.

Authors:  Daniel Patrone; David Resnik; Lisa Chin
Journal:  Biosecur Bioterror       Date:  2012-08-07

2.  Impact of non-welfare interests on willingness to donate to biobanks: an experimental survey.

Authors:  Michele C Gornick; Kerry A Ryan; Scott Y H Kim
Journal:  J Empir Res Hum Res Ethics       Date:  2014-08-11       Impact factor: 1.742

3.  Can Scientists Regulate the Publication of Dual Use Research?

Authors:  David B Resnik
Journal:  Stud Ethics Law Technol       Date:  2010-02

4.  Dual dual-use research of concern: publish and perish?

Authors:  K Satyanarayana
Journal:  Indian J Med Res       Date:  2011-01       Impact factor: 2.375

5.  One study, two paths: the challenge of dual-use research.

Authors:  Wendee Holtcamp
Journal:  Environ Health Perspect       Date:  2012-06       Impact factor: 9.031

6.  The moral concerns of biobank donors: the effect of non-welfare interests on willingness to donate.

Authors:  Raymond G De Vries; Tom Tomlinson; H Myra Kim; Chris D Krenz; Kerry A Ryan; Nicole Lehpamer; Scott Y H Kim
Journal:  Life Sci Soc Policy       Date:  2016-03-11

7.  Understanding the Public's Reservations about Broad Consent and Study-By-Study Consent for Donations to a Biobank: Results of a National Survey.

Authors:  Raymond Gene De Vries; Tom Tomlinson; Hyungjin Myra Kim; Chris Krenz; Diana Haggerty; Kerry A Ryan; Scott Y H Kim
Journal:  PLoS One       Date:  2016-07-14       Impact factor: 3.240

8.  The dual use of research ethics committees: why professional self-governance falls short in preserving biosecurity.

Authors:  Sabine Salloch
Journal:  BMC Med Ethics       Date:  2018-06-05       Impact factor: 2.652

9.  Should all medical research be published? The moral responsibility of medical journal editors.

Authors:  Thomas Ploug
Journal:  J Med Ethics       Date:  2018-06-20       Impact factor: 2.903

10.  Dual-Use Quickscan: A Web-Based Tool to Assess the Dual-Use Potential of Life Science Research.

Authors:  Iris M Vennis; Mirjam M Schaap; Petra A M Hogervorst; Arnout de Bruin; Sjors Schulpen; Marijke A Boot; Mark W J van Passel; Saskia A Rutjes; Diederik A Bleijs
Journal:  Front Bioeng Biotechnol       Date:  2021-12-09
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