Literature DB >> 19783796

Sensitivity of salivary glands to radiation: from animal models to therapies.

O Grundmann1, G C Mitchell, K H Limesand.   

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

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Year:  2009        PMID： 19783796      PMCID： PMC2882712          DOI： 10.1177/0022034509343143

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  100 in total

1.  Radiation apoptosis of serous acinar cells of salivary and lacrimal glands.

Authors:  L C Stephens; T E Schultheiss; R E Price; K K Ang; L J Peters
Journal:  Cancer       Date:  1991-03-15       Impact factor: 6.860

2.  Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer.

Authors:  T A Makkonen; J Tenovuo; P Vilja; A Heimdahl
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1986-09

3.  Response of parotid gland organ culture to radiation.

Authors:  L C Stephens; T E Schultheiss; S M Small; K K Ang; L J Peters
Journal:  Radiat Res       Date:  1989-10       Impact factor: 2.841

4.  Target cell and mode of radiation injury in rhesus salivary glands.

Authors:  L C Stephens; K K Ang; T E Schultheiss; G K King; W A Brock; L J Peters
Journal:  Radiother Oncol       Date:  1986-10       Impact factor: 6.280

5.  Acute and late radiation injury in rhesus monkey parotid glands. Evidence of interphase cell death.

Authors:  L C Stephens; G K King; L J Peters; K K Ang; T E Schultheiss; J H Jardine
Journal:  Am J Pathol       Date:  1986-09       Impact factor: 4.307

Review 6.  Mechanisms of fluid secretion by salivary glands.

Authors:  R J Turner
Journal:  Ann N Y Acad Sci       Date:  1993-09-20       Impact factor: 5.691

Review 7.  Phagocyte recognition of cells undergoing apoptosis.

Authors:  J Savill; V Fadok; P Henson; C Haslett
Journal:  Immunol Today       Date:  1993-03

8.  How much saliva is enough? 'Normal' function defined.

Authors:  J A Ship; P C Fox; B J Baum
Journal:  J Am Dent Assoc       Date:  1991-03       Impact factor: 3.634

9.  Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper.

Authors:  R Nagler; Y Marmary; P C Fox; B J Baum; R Har-El; M Chevion
Journal:  Radiat Res       Date:  1997-04       Impact factor: 2.841

10.  A functional and chemical study of radiation effects on rat parotid and submandibular/sublingual glands.

Authors:  A Vissink; E J 's-Gravenmade; E E Ligeon; W T Konings
Journal:  Radiat Res       Date:  1990-12       Impact factor: 2.841
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  82 in total

1.  Head and neck tumor cell radiation response occurs in the presence of IGF1.

Authors:  K Victory; R Burd; A Fribley; S Sittadjody; D Arnett; R R Klein; K H Limesand
Journal:  J Dent Res       Date:  2010-11-12       Impact factor: 6.116

Review 2.  Salivary Glands: Stem Cells, Self-duplication, or Both?

Authors:  M H Aure; S Arany; C E Ovitt
Journal:  J Dent Res       Date:  2015-08-18       Impact factor: 6.116

3.  Model discrimination in dynamic molecular systems: application to parotid de-differentiation network.

Authors:  Jaejik Kim; Jiaxu Li; Srirangapatnam G Venkatesh; Douglas S Darling; Grzegorz A Rempala
Journal:  J Comput Biol       Date:  2013-07       Impact factor: 1.479

4.  The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.

Authors:  Marilena Vered; Osnat Grinstein-Koren; Shoshana Reiter; Irit Allon; Dan Dayan
Journal:  Int J Exp Pathol       Date:  2010-03-26       Impact factor: 1.925

5.  Botulinum Toxin Confers Radioprotection in Murine Salivary Glands.

Authors:  Youssef H Zeidan; Nan Xiao; Hongbin Cao; Christina Kong; Quynh-Thu Le; Davud Sirjani
Journal:  Int J Radiat Oncol Biol Phys       Date:  2015-12-29       Impact factor: 7.038

Review 6.  Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration.

Authors:  I M A Lombaert; S M Knox; M P Hoffman
Journal:  Oral Dis       Date:  2011-01-11       Impact factor: 3.511

7.  Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics.

Authors:  Rachel Meyer; Wen Yu Wong; Roberto Guzman; Randy Burd; Kirsten Limesand
Journal:  J Vis Exp       Date:  2019-05-17       Impact factor: 1.355

8.  P2X7 receptor activation induces inflammatory responses in salivary gland epithelium.

Authors:  Lucas T Woods; Jean M Camden; Josef M Batek; Michael J Petris; Laurie Erb; Gary A Weisman
Journal:  Am J Physiol Cell Physiol       Date:  2012-08-08       Impact factor: 4.249

Review 9.  Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.

Authors:  Evan L Pannkuk; Albert J Fornace; Evagelia C Laiakis
Journal:  Int J Radiat Biol       Date:  2017-01-12       Impact factor: 2.694

10.  IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter.

Authors:  G C Mitchell; J L Fillinger; S Sittadjody; J L Avila; R Burd; K H Limesand
Journal:  Cell Death Dis       Date:  2010       Impact factor: 8.469
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