BACKGROUND: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. METHODS: We followed a cohort of 8401 asymptomatic individuals (mean age: 53+/-10 years, 69% men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. RESULTS: During a median follow-up period of 5 years, 124 (1.5%) deaths were observed. Overall survival was 96.9% and 98.9% for those with and without detectable TAC, respectively (p<0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95% CI: 2.28-4.65, p<0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95% CI: 1.10-2.27, p=0.015). Likelihood ratio chi(2) statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (chi(2)=13.62, p=0.002) as well as risk factors+CAC (chi(2)=5.84, p=0.02) models. CONCLUSION: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.
BACKGROUND: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. METHODS: We followed a cohort of 8401 asymptomatic individuals (mean age: 53+/-10 years, 69% men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. RESULTS: During a median follow-up period of 5 years, 124 (1.5%) deaths were observed. Overall survival was 96.9% and 98.9% for those with and without detectable TAC, respectively (p<0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95% CI: 2.28-4.65, p<0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95% CI: 1.10-2.27, p=0.015). Likelihood ratio chi(2) statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (chi(2)=13.62, p=0.002) as well as risk factors+CAC (chi(2)=5.84, p=0.02) models. CONCLUSION: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.
Authors: Sila Kurugol; Carolyn E Come; Alejandro A Diaz; James C Ross; Greg L Kinney; Jennifer L Black-Shinn; John E Hokanson; Matthew J Budoff; George R Washko; Raul San Jose Estepar Journal: Med Phys Date: 2015-09 Impact factor: 4.071
Authors: Geoffrey H Tison; Mengye Guo; Michael J Blaha; Robyn L McClelland; Matthew A Allison; Moyses Szklo; Nathan D Wong; Roger S Blumenthal; Matthew J Budoff; Khurram Nasir Journal: J Cardiovasc Comput Tomogr Date: 2015-04-07
Authors: Angelica Ezeigwe; Oluwaseun E Fashanu; Di Zhao; Matthew J Budoff; James D Otvos; Isac C Thomas; Samia Mora; Martin Tibuakuu; Erin D Michos Journal: Atherosclerosis Date: 2019-01-24 Impact factor: 5.162
Authors: Aiman El-Saed; J David Curb; Takashi Kadowaki; Tomonori Okamura; Kim Sutton-Tyrrell; Kamal Masaki; Todd B Seto; Tomoko Takamiya; Jina Choo; Daniel Edmundowicz; Rhobert W Evans; Akira Fujiyoshi; Yasuyuki Nakamura; Katsuyuki Miura; Chol Shin; Lewis H Kuller; Hirotsugu Ueshima; Akira Sekikawa Journal: Int J Cardiol Date: 2012-01-10 Impact factor: 4.164
Authors: Matthew J Budoff; Khurram Nasir; Ronit Katz; Junichiro Takasu; J Jeffery Carr; Nathan D Wong; Matthew Allison; Joao A C Lima; Robert Detrano; Roger S Blumenthal; Richard Kronmal Journal: Atherosclerosis Date: 2010-11-26 Impact factor: 5.162
Authors: Matthew J Budoff; Khurram Nasir; Gregory L Kinney; John E Hokanson; R Graham Barr; Robert Steiner; Hrudaya Nath; Carmen Lopez-Garcia; Jennifer Black-Shinn; Richard Casaburi Journal: J Cardiovasc Comput Tomogr Date: 2010-11-22
Authors: Michael H Criqui; Julie O Denenberg; Robyn L McClelland; Matthew A Allison; Joachim H Ix; Alan Guerci; Kevin P Cohoon; Preethi Srikanthan; Karol E Watson; Nathan D Wong Journal: Arterioscler Thromb Vasc Biol Date: 2014-05-08 Impact factor: 8.311