Asghar Ghasemi1, Saleh Zahediasl, Fereidoun Azizi. 1. Endocrine Physiology Laboratory, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19395-4763, Tehran, Iran.
Abstract
OBJECTIVES: To determine reference values for serum nitric oxide metabolites (nitrite+nitrate=NO(x)) concentrations in adult subjects. DESIGN AND METHODS: Serum NO(x) concentration was measured, using the Griess method, in 694 non-smoking apparently healthy subjects, randomly selected from a population-based study. The International Federation of Clinical Chemistry guidelines and the robust method were used for determining reference values. RESULTS: The 95% reference values for serum NO(x) concentration and serum NO(x)/creatinine ratio were 11.5 to 76.4 micromol/L and 0.111 to 0.729 in men and 10.1 to 65.6 micromol/L and 0.121 to 0.777 in women, respectively. With increasing body mass index, upper limits of serum NO(x) and the NO(x)/creatinine ratio increased in women and decreased in men. Serum NO(x) levels above upper limits predicted both diabetes and metabolic syndrome in women. CONCLUSIONS: This study reports the first set of reference values for serum NO(x) concentration and NO(x)/creatinine ratio in a relatively large healthy non-smoking population. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
OBJECTIVES: To determine reference values for serum nitric oxide metabolites (nitrite+nitrate=NO(x)) concentrations in adult subjects. DESIGN AND METHODS: Serum NO(x) concentration was measured, using the Griess method, in 694 non-smoking apparently healthy subjects, randomly selected from a population-based study. The International Federation of Clinical Chemistry guidelines and the robust method were used for determining reference values. RESULTS: The 95% reference values for serum NO(x) concentration and serum NO(x)/creatinine ratio were 11.5 to 76.4 micromol/L and 0.111 to 0.729 in men and 10.1 to 65.6 micromol/L and 0.121 to 0.777 in women, respectively. With increasing body mass index, upper limits of serum NO(x) and the NO(x)/creatinine ratio increased in women and decreased in men. Serum NO(x) levels above upper limits predicted both diabetes and metabolic syndrome in women. CONCLUSIONS: This study reports the first set of reference values for serum NO(x) concentration and NO(x)/creatinine ratio in a relatively large healthy non-smoking population. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Authors: Gleiciane G Avelar; Wilcelly Machado-Silva; Adriane D Henriques; Jeeser A Almeida; Aparecido P Ferreira; Ciro J Brito; Lucy Gomes; Clayton F Moraes; Otávio T Nóbrega Journal: Int J Mol Epidemiol Genet Date: 2018-06-15
Authors: Kathy K Griendling; Rhian M Touyz; Jay L Zweier; Sergey Dikalov; William Chilian; Yeong-Renn Chen; David G Harrison; Aruni Bhatnagar Journal: Circ Res Date: 2016-07-14 Impact factor: 17.367
Authors: Linda S Pescatello; Elizabeth D Schifano; Garrett I Ash; Gregory A Panza; Lauren M L Corso; Ming-Hui Chen; Ved Deshpande; Amanda Zaleski; Burak Cilhoroz; Paulo Farinatti; Beth A Taylor; Rachel J O'Neill; Paul D Thompson Journal: Physiol Rep Date: 2017-11
Authors: Linda S Pescatello; Elizabeth D Schifano; Garrett I Ash; Gregory A Panza; Lauren Lamberti; Ming-Hui Chen; Ved Deshpande; Amanda Zaleski; Paulo Farinatti; Beth A Taylor; Paul D Thompson Journal: Physiol Rep Date: 2016-10-10