| Literature DB >> 19781443 |
Juwon Kim1, Tae Sung Park, Jaewoo Song, Kyung-A Lee, Duk Jin Hong, Yoo Hong Min, June-Won Cheong, Jong Rak Choi.
Abstract
Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19781443 DOI： 10.1016/j.cancergencyto.2009.06.010
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608