Literature DB >> 19780086

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Alvin W Hung1, H Leonardo Silvestre, Shijun Wen, Alessio Ciulli, Tom L Blundell, Chris Abell.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19780086     DOI： 10.1002/anie.200903821

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


× No keyword cloud information.
  41 in total

Review 1.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

Review 2.  Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

Authors:  Benjamin P Duckworth; Kathryn M Nelson; Courtney C Aldrich
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

3.  Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.

Authors:  Hernani Leonardo Silvestre; Thomas L Blundell; Chris Abell; Alessio Ciulli
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-19       Impact factor: 11.205

4.  A three-stage biophysical screening cascade for fragment-based drug discovery.

Authors:  Ellene H Mashalidis; Paweł Śledź; Steffen Lang; Chris Abell
Journal:  Nat Protoc       Date:  2013-10-24       Impact factor: 13.491

5.  Fragment-based lead discovery: challenges and opportunities.

Authors:  Chaohong Sun; Andrew M Petros; Philip J Hajduk
Journal:  J Comput Aided Mol Des       Date:  2011-07-06       Impact factor: 3.686

6.  Ligand deconstruction: Why some fragment binding positions are conserved and others are not.

Authors:  Dima Kozakov; David R Hall; Stefan Jehle; Sefan Jehle; Lingqi Luo; Stefan O Ochiana; Elizabeth V Jones; Michael Pollastri; Karen N Allen; Adrian Whitty; Sandor Vajda
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-27       Impact factor: 11.205

Review 7.  The tuberculosis drug discovery and development pipeline and emerging drug targets.

Authors:  Khisimuzi Mdluli; Takushi Kaneko; Anna Upton
Journal:  Cold Spring Harb Perspect Med       Date:  2015-01-29       Impact factor: 6.915

8.  Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Authors:  Zhixiang Xu; Wei Yin; Leonardo K Martinelli; Joanna Evans; Jinglei Chen; Yang Yu; Daniel J Wilson; Valerie Mizrahi; Chunhua Qiao; Courtney C Aldrich
Journal:  Bioorg Med Chem       Date:  2014-01-23       Impact factor: 3.641

9.  Route to three-dimensional fragments using diversity-oriented synthesis.

Authors:  Alvin W Hung; Alex Ramek; Yikai Wang; Taner Kaya; J Anthony Wilson; Paul A Clemons; Damian W Young
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

10.  Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.

Authors:  Garth L Abrahams; Anuradha Kumar; Suzana Savvi; Alvin W Hung; Shijun Wen; Chris Abell; Clifton E Barry; David R Sherman; Helena I M Boshoff; Valerie Mizrahi
Journal:  Chem Biol       Date:  2012-07-27
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.