Literature DB >> 19778006

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase.

Leighanne A Brammer1, Caren Freel Meyers.   

Abstract

A study of DXP synthase has revealed flexibility in the acceptor substrate binding pocket for nonpolar substrates and has uncovered new details of the catalytic mechanism to show that pyruvate can act as both donor and acceptor substrate.

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Year:  2009        PMID： 19778006      PMCID： PMC2761658          DOI： 10.1021/ol901961q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

1.  High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection.

Authors:  Ying-Shan Han; Cesare Sabbioni; Robert van der Heijden; Robert Verpoorte
Journal:  J Chromatogr A       Date:  2003-02-07       Impact factor: 4.759

2.  Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis.

Authors:  T Kuzuyama; M Takagi; S Takahashi; H Seto
Journal:  J Bacteriol       Date:  2000-02       Impact factor: 3.490

3.  Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

Authors:  L M Lois; N Campos; S R Putra; K Danielsen; M Rohmer; A Boronat
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

4.  Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate.

Authors:  M Rohmer; M Knani; P Simonin; B Sutter; H Sahm
Journal:  Biochem J       Date:  1993-10-15       Impact factor: 3.857

5.  1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus.

Authors:  F M Hahn; L M Eubanks; C A Testa; B S Blagg; J A Baker; C D Poulter
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

6.  Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde.

Authors:  Edward G Hibbert; Tarik Senussi; Mark E B Smith; Sean J Costelloe; John M Ward; Helen C Hailes; Paul A Dalby
Journal:  J Biotechnol       Date:  2008-02-13       Impact factor: 3.307

Review 7.  Thiamin diphosphate in biological chemistry: exploitation of diverse thiamin diphosphate-dependent enzymes for asymmetric chemoenzymatic synthesis.

Authors:  Michael Müller; Dörte Gocke; Martina Pohl
Journal:  FEBS J       Date:  2009-04-23       Impact factor: 5.542

8.  Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.

Authors:  Ann Marie Bailey; Sebabrata Mahapatra; Patrick J Brennan; Dean C Crick
Journal:  Glycobiology       Date:  2002-12       Impact factor: 4.313

9.  Rhodobacter capsulatus 1-deoxy-D-xylulose 5-phosphate synthase: steady-state kinetics and substrate binding.

Authors:  Lisa M Eubanks; C Dale Poulter
Journal:  Biochemistry       Date:  2003-02-04       Impact factor: 3.162

Review 10.  The methylerythritol phosphate pathway and its significance as a novel drug target.

Authors:  C A Testa; M J Brown
Journal:  Curr Pharm Biotechnol       Date:  2003-08       Impact factor: 2.837
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  24 in total

1.  A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.

Authors:  Wesley Wu; Zachary Herrera; Danny Ebert; Katie Baska; Seok H Cho; Joseph L DeRisi; Ellen Yeh
Journal:  Antimicrob Agents Chemother       Date:  2014-11-03       Impact factor: 5.191

2.  Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Authors:  Sara Sanders; Ryan J Vierling; David Bartee; Alicia A DeColli; Mackenzie J Harrison; Joseph L Aklinski; Andrew T Koppisch; Caren L Freel Meyers
Journal:  ACS Infect Dis       Date:  2017-06-21       Impact factor: 5.084

3.  X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

Authors:  Percival Yang-Ting Chen; Alicia A DeColli; Caren L Freel Meyers; Catherine L Drennan
Journal:  J Biol Chem       Date:  2019-06-25       Impact factor: 5.157

4.  Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.

Authors:  David Bartee; Francine Morris; Amer Al-Khouja; Caren L Freel Meyers
Journal:  Chembiochem       Date:  2015-07-15       Impact factor: 3.164

5.  Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.

Authors:  Leighanne A Brammer Basta; Hetalben Patel; Lazaros Kakalis; Frank Jordan; Caren L Freel Meyers
Journal:  FEBS J       Date:  2014-05-12       Impact factor: 5.542

6.  Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.

Authors:  David Bartee; Caren L Freel Meyers
Journal:  Biochemistry       Date:  2018-07-06       Impact factor: 3.162

7.  Improving 2-phenylethanol production via Ehrlich pathway using genetic engineered Saccharomyces cerevisiae strains.

Authors:  Sheng Yin; Hui Zhou; Xiao Xiao; Tiandan Lang; Jingru Liang; Chengtao Wang
Journal:  Curr Microbiol       Date:  2015-02-14       Impact factor: 2.188

8.  Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates().

Authors:  Jessica M Smith; Ryan J Vierling; Caren Freel Meyers
Journal:  Medchemcomm       Date:  2011-10-26       Impact factor: 3.597

9.  Determination of the Activity of 1-Deoxy-D-Xylulose 5-Phosphate Synthase by Pre-column Derivatization-HPLC Using 1,2-Diamino-4,5-Methylenedioxybenzene as a Derivatizing Reagent.

Authors:  Yan-Fei Liang; Hui Liu; Heng Li; Wen-Yun Gao
Journal:  Protein J       Date:  2019-04       Impact factor: 2.371

10.  Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.

Authors:  Hetalben Patel; Natalia S Nemeria; Leighanne A Brammer; Caren L Freel Meyers; Frank Jordan
Journal:  J Am Chem Soc       Date:  2012-10-26       Impact factor: 15.419
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