AIM: To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS: Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study. p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS: The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION: These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.
AIM: To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS: Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study. p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS: The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION: These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.
Authors: J Alves-Silva; M da Silva Santos; P E Guimarães; A C Ferreira; H J Bandelt; S D Pena; V F Prado Journal: Am J Hum Genet Date: 2000-06-28 Impact factor: 11.025
Authors: G Rezza; M Giuliani; A R Garbuglia; D Serraino; G Cappiello; G Migliore; M Branca; A Benedetto; G Ippolito Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-05 Impact factor: 4.254
Authors: Sidia M Callegari-Jacques; Dario Grattapaglia; Francisco M Salzano; Sabrina P Salamoni; Shaiane G Crossetti; Márcio E Ferreira; Mara H Hutz Journal: Am J Hum Biol Date: 2003 Nov-Dec Impact factor: 1.937
Authors: R Fan; M T Wu; D Miller; J C Wain; K T Kelsey; J K Wiencke; D C Christiani Journal: Cancer Epidemiol Biomarkers Prev Date: 2000-10 Impact factor: 4.254