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Literature DB >> 19776745

p53 ancestry: gazing through an evolutionary lens.

Wan-Jin Lu¹, James F Amatruda, John M Abrams.

Abstract

Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19776745 DOI： 10.1038/nrc2732

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

58 in total

1. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.

Authors: A J MacQueen; A M Villeneuve
Journal: Genes Dev Date: 2001-07-01 Impact factor: 11.361

Review 2. Casting a genetic light on the evolution of eyes.

Authors: Russell D Fernald
Journal: Science Date: 2006-09-29 Impact factor: 47.728

3. Stimulation of autophagy by the p53 target gene Sestrin2.

Authors: Maria Chiara Maiuri; Shoaib Ahmad Malik; Eugenia Morselli; Oliver Kepp; Alfredo Criollo; Pierre-Luc Mouchel; Rosa Carnuccio; Guido Kroemer
Journal: Cell Cycle Date: 2009-05-20 Impact factor: 4.534

4. p53 suppresses the self-renewal of adult neural stem cells.

Authors: Konstantinos Meletis; Valtteri Wirta; Sanna-Maria Hede; Monica Nistér; Joakim Lundeberg; Jonas Frisén
Journal: Development Date: 2006-01 Impact factor: 6.868

5. p53 directs focused genomic responses in Drosophila.

Authors: F Akdemir; A Christich; N Sogame; J Chapo; J M Abrams
Journal: Oncogene Date: 2007-02-19 Impact factor: 9.867

Review 6. Prognostic and predictive value of p53 and p21 in breast cancer.

Authors: R M Elledge; D C Allred
Journal: Breast Cancer Res Treat Date: 1998 Impact factor: 4.872

7. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.

Authors: S N Jones; A E Roe; L A Donehower; A Bradley
Journal: Nature Date: 1995-11-09 Impact factor: 49.962

8. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

Authors: Nicole King; M Jody Westbrook; Susan L Young; Alan Kuo; Monika Abedin; Jarrod Chapman; Stephen Fairclough; Uffe Hellsten; Yoh Isogai; Ivica Letunic; Michael Marr; David Pincus; Nicholas Putnam; Antonis Rokas; Kevin J Wright; Richard Zuzow; William Dirks; Matthew Good; David Goodstein; Derek Lemons; Wanqing Li; Jessica B Lyons; Andrea Morris; Scott Nichols; Daniel J Richter; Asaf Salamov; J G I Sequencing; Peer Bork; Wendell A Lim; Gerard Manning; W Todd Miller; William McGinnis; Harris Shapiro; Robert Tjian; Igor V Grigoriev; Daniel Rokhsar
Journal: Nature Date: 2008-02-14 Impact factor: 49.962

Review 9. p73 and p63 protein stability: the way to regulate function?

Authors: Carine Maisse; Piero Guerrieri; Gerry Melino
Journal: Biochem Pharmacol Date: 2003-10-15 Impact factor: 5.858

10. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

Authors: Richard Tomasini; Katsuya Tsuchihara; Margareta Wilhelm; Masashi Fujitani; Alessandro Rufini; Carol C Cheung; Fatima Khan; Annick Itie-Youten; Andrew Wakeham; Ming-Sound Tsao; Juan L Iovanna; Jeremy Squire; Igor Jurisica; David Kaplan; Gerry Melino; Andrea Jurisicova; Tak W Mak
Journal: Genes Dev Date: 2008-09-19 Impact factor: 11.361

58 in total

Review 1. p53 at a glance.

Authors: Colleen A Brady; Laura D Attardi
Journal: J Cell Sci Date: 2010-08-01 Impact factor: 5.285

2. The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.

Authors: Katelyn M Atkins; Laura L Thomas; Jonathan Barroso-González; Laurel Thomas; Sylvain Auclair; Jun Yin; Hyeog Kang; Jay H Chung; Jimmy D Dikeakos; Gary Thomas
Journal: Cell Rep Date: 2014-08-21 Impact factor: 9.423

Review 3. The p53 orchestra: Mdm2 and Mdmx set the tone.

Authors: Mark Wade; Yunyuan V Wang; Geoffrey M Wahl
Journal: Trends Cell Biol Date: 2010-02-19 Impact factor: 20.808

4. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.

Authors: Jie Zhuang; Ping-yuan Wang; Xinglu Huang; Xiaoyuan Chen; Ju-Gyeong Kang; Paul M Hwang
Journal: Proc Natl Acad Sci U S A Date: 2013-10-07 Impact factor: 11.205

5. Meiotic recombination provokes functional activation of the p53 regulatory network.

Authors: Wan-Jin Lu; Joseph Chapo; Ignasi Roig; John M Abrams
Journal: Science Date: 2010-06-04 Impact factor: 47.728

Review 6. Transposons, p53 and Genome Security.

Authors: Bhavana Tiwari; Amanda E Jones; John M Abrams
Journal: Trends Genet Date: 2018-09-05 Impact factor: 11.639

7. Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Transcription to Overcome Tumorigenesis in Non-small Cell Lung Cancer.

Authors: Amjad Ali; Muhammad Zeeshan Bhatti; Abdus Saboor Shah; Hong-Quan Duong; Huda Mohammad Alkreathy; Shah Faisal Mohammad; Rahmat Ali Khan; Ayaz Ahmad
Journal: J Biol Chem Date: 2015-04-24 Impact factor: 5.157

8. Dipeptide analysis of p53 mutations and evolution of p53 family proteins.

Authors: Qiang Huang; Long Yu; Arnold J Levine; Ruth Nussinov; Buyong Ma
Journal: Biochim Biophys Acta Date: 2013-04-10

Review 9. Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?

Authors: Jie Zhuang; Wenzhe Ma; Cory U Lago; Paul M Hwang
Journal: Free Radic Biol Med Date: 2012-07-25 Impact factor: 7.376

10. Increased oxidative metabolism in the Li-Fraumeni syndrome.

Authors: Ping-Yuan Wang; Wenzhe Ma; Joon-Young Park; Francesco S Celi; Ross Arena; Jeong W Choi; Qais A Ali; Dotti J Tripodi; Jie Zhuang; Cory U Lago; Louise C Strong; S Lalith Talagala; Robert S Balaban; Ju-Gyeong Kang; Paul M Hwang
Journal: N Engl J Med Date: 2013-03-14 Impact factor: 91.245