| Literature DB >> 18273011 |
Nicole King1, M Jody Westbrook, Susan L Young, Alan Kuo, Monika Abedin, Jarrod Chapman, Stephen Fairclough, Uffe Hellsten, Yoh Isogai, Ivica Letunic, Michael Marr, David Pincus, Nicholas Putnam, Antonis Rokas, Kevin J Wright, Richard Zuzow, William Dirks, Matthew Good, David Goodstein, Derek Lemons, Wanqing Li, Jessica B Lyons, Andrea Morris, Scott Nichols, Daniel J Richter, Asaf Salamov, J G I Sequencing, Peer Bork, Wendell A Lim, Gerard Manning, W Todd Miller, William McGinnis, Harris Shapiro, Robert Tjian, Igor V Grigoriev, Daniel Rokhsar.
Abstract
Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron-rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.Entities:
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Year: 2008 PMID： 18273011 PMCID： PMC2562698 DOI： 10.1038/nature06617
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962