Literature DB >> 19774103

Statistical issues in the analysis of DNA Copy Number Variations.

Nathan E Wineinger1, Richard E Kennedy, Stephen W Erickson, Mary K Wojczynski, Carl E Bruder, Hemant K Tiwari.   

Abstract

Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis.

Keywords:  CBS; DNA; GWAS; array CGH; calling algorithm; circular binary segmentation; complex disorders; copy number; genome-wide association study; hidden Markov model; microarray; normalization; whole genome amplification

Mesh：

Substances：

Year:  2008        PMID： 19774103      PMCID： PMC2747762          DOI： 10.1504/IJCBDD.2008.022208

Source DB:  PubMed          Journal:  Int J Comput Biol Drug Des        ISSN： 1756-0756


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