OBJECTIVE: To evaluate the cross-sectional relationship of anthropometric measures (body mass index (BMI) and visceral fat and the adipokines leptin and adiponectin) with telomere length in a racially diverse sample. DESIGN: Cross-sectional study of participants recruited from a health science university. SUBJECTS: Participants include 317 men and women aged 40-64 years without diagnosed diabetes, cardiovascular disease (defined as coronary heart disease or stroke/transient ischemic attack) or cancer. RESULTS: Study participants were 54.9% female, 58% non-Hispanic white (NHW) and 42% non-Hispanic Black (NHB). Of the sample, 76% were either overweight or obese. Linear regressions showed no association between the anthropometric measures (BMI (kg m(-2)), visceral fat (cm(2)), adiponectin (microg ml(-1)), leptin (ng ml(-1)) or adiponectin to leptin ratio (microg ng(-1))) assessed in a continuous manner and telomere length assay ratio, either for the whole sample or when stratified by race or by gender. CONCLUSION: This study finds no linear associations between telomere length and several measures of obesity in a sample of NHB and NHW men and women. Further studies are needed to identify factors that influence telomere length in diverse populations.
OBJECTIVE: To evaluate the cross-sectional relationship of anthropometric measures (body mass index (BMI) and visceral fat and the adipokines leptin and adiponectin) with telomere length in a racially diverse sample. DESIGN: Cross-sectional study of participants recruited from a health science university. SUBJECTS:Participants include 317 men and women aged 40-64 years without diagnosed diabetes, cardiovascular disease (defined as coronary heart disease or stroke/transient ischemic attack) or cancer. RESULTS: Study participants were 54.9% female, 58% non-Hispanic white (NHW) and 42% non-Hispanic Black (NHB). Of the sample, 76% were either overweight or obese. Linear regressions showed no association between the anthropometric measures (BMI (kg m(-2)), visceral fat (cm(2)), adiponectin (microg ml(-1)), leptin (ng ml(-1)) or adiponectin to leptin ratio (microg ng(-1))) assessed in a continuous manner and telomere length assay ratio, either for the whole sample or when stratified by race or by gender. CONCLUSION: This study finds no linear associations between telomere length and several measures of obesity in a sample of NHB and NHW men and women. Further studies are needed to identify factors that influence telomere length in diverse populations.
Authors: Marissa Rewak; Stephen Buka; Jennifer Prescott; Immaculata De Vivo; Eric B Loucks; Ichiro Kawachi; Amy L Non; Laura D Kubzansky Journal: Biol Psychol Date: 2014-03-29 Impact factor: 3.251
Authors: O T Njajou; R M Cawthon; E H Blackburn; T B Harris; R Li; J L Sanders; A B Newman; M Nalls; S R Cummings; W-C Hsueh Journal: Int J Obes (Lond) Date: 2011-10-18 Impact factor: 5.095
Authors: Marij Gielen; Geja J Hageman; Evangelia E Antoniou; Katarina Nordfjall; Massimo Mangino; Muthuswamy Balasubramanyam; Tim de Meyer; Audrey E Hendricks; Erik J Giltay; Steven C Hunt; Jennifer A Nettleton; Klelia D Salpea; Vanessa A Diaz; Ramin Farzaneh-Far; Gil Atzmon; Sarah E Harris; Lifang Hou; David Gilley; Iiris Hovatta; Jeremy D Kark; Hisham Nassar; David J Kurz; Karen A Mather; Peter Willeit; Yun-Ling Zheng; Sofia Pavanello; Ellen W Demerath; Line Rode; Daniel Bunout; Andrew Steptoe; Lisa Boardman; Amelia Marti; Belinda Needham; Wei Zheng; Rosalind Ramsey-Goldman; Andrew J Pellatt; Jaakko Kaprio; Jonathan N Hofmann; Christian Gieger; Giuseppe Paolisso; Jacob B H Hjelmborg; Lisa Mirabello; Teresa Seeman; Jason Wong; Pim van der Harst; Linda Broer; Florian Kronenberg; Barbara Kollerits; Timo Strandberg; Dan T A Eisenberg; Catherine Duggan; Josine E Verhoeven; Roxanne Schaakxs; Raffaela Zannolli; Rosana M R Dos Reis; Fadi J Charchar; Maciej Tomaszewski; Ute Mons; Ilja Demuth; Andrea Elena Iglesias Molli; Guo Cheng; Dmytro Krasnienkov; Bianca D'Antono; Marek Kasielski; Barry J McDonnell; Richard Paul Ebstein; Kristina Sundquist; Guillaume Pare; Michael Chong; Maurice P Zeegers Journal: Am J Clin Nutr Date: 2018-09-01 Impact factor: 7.045
Authors: Linda Broer; Julia Raschenberger; Joris Deelen; Massimo Mangino; Veryan Codd; Kirsi H Pietiläinen; Eva Albrecht; Najaf Amin; Marian Beekman; Anton J M de Craen; Christian Gieger; Margot Haun; Peter Henneman; Christian Herder; Iiris Hovatta; Annika Laser; Lyudmyla Kedenko; Wolfgang Koenig; Barbara Kollerits; Eeva Moilanen; Ben A Oostra; Bernhard Paulweber; Lydia Quaye; Aila Rissanen; Michael Roden; Ida Surakka; Ana M Valdes; Katriina Vuolteenaho; Barbara Thorand; Ko Willems van Dijk; Jaakko Kaprio; Tim D Spector; P Eline Slagboom; Nilesh J Samani; Florian Kronenberg; Cornelia M van Duijn; Karl-Heinz Ladwig Journal: Eur J Epidemiol Date: 2014-07-27 Impact factor: 8.082
Authors: S García-Calzón; A Gea; C Razquin; D Corella; R M Lamuela-Raventós; J A Martínez; M A Martínez-González; G Zalba; A Marti Journal: Int J Obes (Lond) Date: 2013-05-06 Impact factor: 5.095