Marcia Garnica1, Marcio Nucci, Flavio Queiroz-Telles. 1. Department of Internal Medicine, Hematology Unit and Mycology Laboratory, University Hospital, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, Rio de Janeiro, Brazil.
Abstract
PURPOSE OF REVIEW: Eumycetoma, phaeohyphomycosis and chromoblastomycosis are subcutaneous mycoses having in common the fact that they are acquired as a result of penetrating trauma to the skin and may be caused by a large variety of fungi. This article will review recent data regarding the epidemiology and treatment of these infections. RECENT FINDINGS: Recent epidemiologic observations in these mycoses include an increased incidence of phaeohyphomycosis in immunosuppressed patients, the association of polymorphisms in genes involved in innate immunity, the occurrence of eumycetoma caused by Madurella mycetomatis and the nosocomial acquisition of phaeohyphomycosis. The management of these infections continues to be challenging. An approach that involves early diagnosis, the use of systemic antifungal agents and local therapies, including surgical removal of lesions, is the basis of the treatment of these diseases. SUMMARY: It is crucial that the epidemiology and clinical presentation of these infections are understood if we are to improve their outcomes.
PURPOSE OF REVIEW: Eumycetoma, phaeohyphomycosis and chromoblastomycosis are subcutaneous mycoses having in common the fact that they are acquired as a result of penetrating trauma to the skin and may be caused by a large variety of fungi. This article will review recent data regarding the epidemiology and treatment of these infections. RECENT FINDINGS: Recent epidemiologic observations in these mycoses include an increased incidence of phaeohyphomycosis in immunosuppressed patients, the association of polymorphisms in genes involved in innate immunity, the occurrence of eumycetoma caused by Madurella mycetomatis and the nosocomial acquisition of phaeohyphomycosis. The management of these infections continues to be challenging. An approach that involves early diagnosis, the use of systemic antifungal agents and local therapies, including surgical removal of lesions, is the basis of the treatment of these diseases. SUMMARY: It is crucial that the epidemiology and clinical presentation of these infections are understood if we are to improve their outcomes.
Authors: Peggy A Wu; Maria L Turner; Edward W Cowen; Eleanor Wilson; Yvonne R Shea; Timothy Jancel; Alexandra F Freeman Journal: J Am Acad Dermatol Date: 2010-12 Impact factor: 11.527
Authors: Katharine E Cartwright; Tristan W Clark; Abid M Hussain; Martin Wiselka; Andrew Borman; Elizabeth M Johnson Journal: Mycopathologia Date: 2011-05-13 Impact factor: 2.574
Authors: Mohammad J Najafzadeh; Hamid Badali; Maria Teresa Illnait-Zaragozi; G Sybren De Hoog; Jacques F Meis Journal: Antimicrob Agents Chemother Date: 2010-01-19 Impact factor: 5.191