Jessica Risser1, Kevan Lewis, Martin A Weinstock. 1. Dermatoepidemiology Unit, Veterans Affairs Medical Center, Mail Stop 111D, 830 Chalkstone Ave, Providence, RI 02908, USA.
Abstract
OBJECTIVES: To identify and analyze trends in bullous disease mortality from 1979 through 2002 in the United States. DESIGN: Retrospective population-based analysis. SETTING: Mortality records from the Centers for Disease Control and Prevention mortality database. PARTICIPANTS: Mortality records from 1979 through 2002 for persons who died of bullous disease. MAIN OUTCOME MEASURES: Age-adjusted mortality rates and trends for 4 bullous disease subgroups: toxic epidermal necrolysis, pemphigoid, pemphigus, and epidermolysis bullosa. RESULTS: The overall age-adjusted (to the 2000 US standard population) annual mortality rate from bullous diseases of the skin was 0.103 death per 100 000. The average mortality from bullous disorders was 0.098 per 100 000 in 1979 through 1982 and remained stable at 0.099 per 100 000 during the final 4 years of the study, 1999 through 2002. Pemphigoid had a significant increase in mortality from 1979 through 2002, while pemphigus demonstrated a significant decrease in mortality. The mortality rate for toxic epidermal necrolysis was much higher among blacks (0.192 death per 100 000) than whites (0.025 per 100 000) (P < .001), with a mortality rate ratio of 7.57 (95% confidence interval, 6.97-8.21). CONCLUSIONS: Overall mortality from bullous diseases remained stable from 1979 through 2002, although an increasing mortality from pemphigoid and a decreasing mortality from pemphigus occurred during this period. A very large racial disparity in mortality from toxic epidermal necrolysis was observed.
OBJECTIVES: To identify and analyze trends in bullous disease mortality from 1979 through 2002 in the United States. DESIGN: Retrospective population-based analysis. SETTING: Mortality records from the Centers for Disease Control and Prevention mortality database. PARTICIPANTS: Mortality records from 1979 through 2002 for persons who died of bullous disease. MAIN OUTCOME MEASURES: Age-adjusted mortality rates and trends for 4 bullous disease subgroups: toxic epidermal necrolysis, pemphigoid, pemphigus, and epidermolysis bullosa. RESULTS: The overall age-adjusted (to the 2000 US standard population) annual mortality rate from bullous diseases of the skin was 0.103 death per 100 000. The average mortality from bullous disorders was 0.098 per 100 000 in 1979 through 1982 and remained stable at 0.099 per 100 000 during the final 4 years of the study, 1999 through 2002. Pemphigoid had a significant increase in mortality from 1979 through 2002, while pemphigus demonstrated a significant decrease in mortality. The mortality rate for toxic epidermal necrolysis was much higher among blacks (0.192 death per 100 000) than whites (0.025 per 100 000) (P < .001), with a mortality rate ratio of 7.57 (95% confidence interval, 6.97-8.21). CONCLUSIONS: Overall mortality from bullous diseases remained stable from 1979 through 2002, although an increasing mortality from pemphigoid and a decreasing mortality from pemphigus occurred during this period. A very large racial disparity in mortality from toxic epidermal necrolysis was observed.
Authors: R P Hall; J Fairley; D Woodley; V P Werth; D Hannah; R D Streilein; J McKillip; J Okawa; M Rose; L L Keyes-Elstein; A Pinckney; A Overington; J Wedgwood; L Ding; B Welch Journal: Br J Dermatol Date: 2015-02-05 Impact factor: 9.302
Authors: Katherine E Brick; Chad H Weaver; Christine M Lohse; Mark R Pittelkow; Julia S Lehman; Michael J Camilleri; Mustafa Al-Hashimi; Carilyn N Wieland Journal: J Am Acad Dermatol Date: 2014-04-03 Impact factor: 11.527
Authors: Vanessa Lys Simas Yamakawa Boeira; Erica Sales Souza; Bruno de Oliveira Rocha; Pedro Dantas Oliveira; Maria de Fátima Santos Paim de Oliveira; Vitória Regina Pedreira de Almeida Rêgo; Ivonise Follador Journal: An Bras Dermatol Date: 2013 Mar-Apr Impact factor: 1.896