K Kridin1, S Zelber-Sagi2, D Comaneshter3, A D Cohen3. 1. Department of Dermatology,Rambam Health Care Campus,Haifa,Israel. 2. School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa,Haifa,Israel. 3. Department of Quality Measurements and Research,Chief Physician's Office,Clalit Health Services,Tel Aviv,Israel.
Abstract
AIMS: Immunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database. METHODS: This study was conducted as a cross-sectional study utilising the database of Clalit Health Services. The proportion of schizophrenia was compared between patients diagnosed with pemphigus and age-, gender- and ethnicity-matched control subjects. Univariate analysis was performed using χ2 and Student's t-test and a multivariate analysis was performed using a logistic regression model. RESULTS: A total of 1985 pemphigus patients and 9874 controls were included in the study. The prevalence of schizophrenia was greater in patients with pemphigus as compared to the control group (2.0% v. 1.3%, respectively; p = 0.019). In a multivariate analysis, pemphigus was significantly associated with schizophrenia (OR, 1.5; 95% CI, 1.1-2.2). The association was more prominent among females, patients older than 60 years, and Jews. CONCLUSIONS: Pemphigus is significantly associated with schizophrenia. Physicians treating patients with pemphigus should be aware of this possible association. Patients with pemphigus should be carefully assessed for comorbid schizophrenia and be treated appropriately.
AIMS: Immunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database. METHODS: This study was conducted as a cross-sectional study utilising the database of Clalit Health Services. The proportion of schizophrenia was compared between patients diagnosed with pemphigus and age-, gender- and ethnicity-matched control subjects. Univariate analysis was performed using χ2 and Student's t-test and a multivariate analysis was performed using a logistic regression model. RESULTS: A total of 1985 pemphigus patients and 9874 controls were included in the study. The prevalence of schizophrenia was greater in patients with pemphigus as compared to the control group (2.0% v. 1.3%, respectively; p = 0.019). In a multivariate analysis, pemphigus was significantly associated with schizophrenia (OR, 1.5; 95% CI, 1.1-2.2). The association was more prominent among females, patients older than 60 years, and Jews. CONCLUSIONS: Pemphigus is significantly associated with schizophrenia. Physicians treating patients with pemphigus should be aware of this possible association. Patients with pemphigus should be carefully assessed for comorbid schizophrenia and be treated appropriately.
Authors: William W Eaton; Majella Byrne; Henrik Ewald; Ole Mors; Chuan-Yu Chen; Esben Agerbo; Preben Bo Mortensen Journal: Am J Psychiatry Date: 2006-03 Impact factor: 18.112
Authors: Todd Lencz; Saurav Guha; Chunyu Liu; Jeffrey Rosenfeld; Semanti Mukherjee; Pamela DeRosse; Majnu John; Lijun Cheng; Chunling Zhang; Judith A Badner; Masashi Ikeda; Nakao Iwata; Sven Cichon; Marcella Rietschel; Markus M Nöthen; A T A Cheng; Colin Hodgkinson; Qiaoping Yuan; John M Kane; Annette T Lee; Anne Pisanté; Peter K Gregersen; Itsik Pe'er; Anil K Malhotra; David Goldman; Ariel Darvasi Journal: Nat Commun Date: 2013 Impact factor: 14.919
Authors: Alexis E Cullen; Scarlett Holmes; Thomas A Pollak; Graham Blackman; Dan W Joyce; Matthew J Kempton; Robin M Murray; Philip McGuire; Valeria Mondelli Journal: Biol Psychiatry Date: 2018-06-28 Impact factor: 13.382