| Literature DB >> 19769334 |
Erwan Le Gall1, Caroline Haurena, Stéphane Sengmany, Thierry Martens, Michel Troupel.
Abstract
An array of alpha-branched amines has been prepared by using an expedient three-component Mannich-type reaction among organic halides, aldehyde derivatives, and amines. The experimental procedure, which is characterized by its simplicity, employs zinc dust for the in situ generation of organozinc reagents. We show that this Barbier-like protocol constitutes a useful entry to diarylmethylamines, 1,2-diarylethylamines, alpha- or beta-amino esters, benzylamines, and beta-arylethylamines.Entities:
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Year: 2009 PMID： 19769334 DOI： 10.1021/jo901704s
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354