Literature DB >> 19768775

Hsp70 molecular chaperones and Parkinson's disease.

Stephan N Witt1.   

Abstract

Because over expression of Hsp70 molecular chaperones suppresses the toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and various polyQ-diseases (Huntington's disease and ataxias), Hsp70 is garnering attention as a possible therapeutic agent for these various diseases. Here, I review progress in this fascinating field of molecular chaperones and neurodegeneration and describe our current understanding of the mechanisms by which Hsp70 protects cells from the PD-related protein called alpha-synuclein (alpha-syn). (c) 2009 Wiley Periodicals, Inc.

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Year:  2010        PMID： 19768775     DOI： 10.1002/bip.21302

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.505


  32 in total

1.  High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

Authors:  Yoshinari Miyata; Lyra Chang; Anthony Bainor; Thomas J McQuade; Christopher P Walczak; Yaru Zhang; Martha J Larsen; Paul Kirchhoff; Jason E Gestwicki
Journal:  J Biomol Screen       Date:  2010-10-06

2.  Heat, pH induced aggregation and surface hydrophobicity of S. cerevesiae Ssa1 protein.

Authors:  Yusuf Tutar; Derya Arslan; Lütfi Tutar
Journal:  Protein J       Date:  2010-10       Impact factor: 2.371

3.  Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.

Authors:  Samantha Pemberton; Karine Madiona; Laura Pieri; Mehdi Kabani; Luc Bousset; Ronald Melki
Journal:  J Biol Chem       Date:  2011-08-10       Impact factor: 5.157

Review 4.  Heat shock protein 70 (hsp70) as an emerging drug target.

Authors:  Christopher G Evans; Lyra Chang; Jason E Gestwicki
Journal:  J Med Chem       Date:  2010-06-24       Impact factor: 7.446

5.  Adaptation and sensitization to proteotoxic stress.

Authors:  Rehana K Leak
Journal:  Dose Response       Date:  2013-08-05       Impact factor: 2.658

6.  Prion Efficiently Replicates in α-Synuclein Knockout Mice.

Authors:  Edoardo Bistaffa; Martina Rossi; Chiara Maria Giulia De Luca; Federico Cazzaniga; Olga Carletta; Ilaria Campagnani; Fabrizio Tagliavini; Giuseppe Legname; Giorgio Giaccone; Fabio Moda
Journal:  Mol Neurobiol       Date:  2019-04-30       Impact factor: 5.590

7.  Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.

Authors:  Susana Gonçalves; Tiago Fleming Outeiro
Journal:  Mol Neurobiol       Date:  2013-02-08       Impact factor: 5.590

8.  Identification of protein interfaces between α-synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p.

Authors:  Virginie Redeker; Samantha Pemberton; Willy Bienvenut; Luc Bousset; Ronald Melki
Journal:  J Biol Chem       Date:  2012-07-26       Impact factor: 5.157

Review 9.  Molecular chaperones, α-synuclein, and neurodegeneration.

Authors:  Stephan N Witt
Journal:  Mol Neurobiol       Date:  2012-08-25       Impact factor: 5.590

10.  Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.

Authors:  Venu Talla; Vittorio Porciatti; Vince Chiodo; Sanford L Boye; William W Hauswirth; John Guy
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-07-11       Impact factor: 4.799
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