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Literature DB >> 19766559

p53: a new kingpin in the stem cell arena.

Abstract

Identifying new regulators of the stem cell state offers potential for future gains in biomedicine. Evidence that the tumor suppressor p53 is a key regulator of the stem cell state (Cicalese et al., 2009) suggests a broad role for this protein and its pathways in the control of normal tissue homeostasis and tumor formation.

Entities: Chemical Disease Gene

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Year: 2009 PMID： 19766559 DOI： 10.1016/j.cell.2009.09.004

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

12 in total

1. IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.

Authors: R Kibe; S Zhang; D Guo; L Marrero; F Tsien; P Rodriguez; S Khan; A Zieske; J Huang; W Li; S K Durum; T Iwakuma; Y Cui
Journal: Cell Death Differ Date: 2012-01-27 Impact factor: 15.828

2. NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

Authors: Hifzur R Siddique; Douglas E Feldman; Chia-Lin Chen; Vasu Punj; Hiroshi Tokumitsu; Keigo Machida
Journal: Hepatology Date: 2015-08-28 Impact factor: 17.425

3. MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

Authors: Hirofumi Akita; Jens U Marquardt; Marian E Durkin; Mitsuteru Kitade; Daekwan Seo; Elizabeth A Conner; Jesper B Andersen; Valentina M Factor; Snorri S Thorgeirsson
Journal: Cancer Res Date: 2014-09-04 Impact factor: 12.701

4. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.

Authors: Shuzhong Zhang; Mingquan Zheng; Ryoko Kibe; Yunping Huang; Luis Marrero; Samantha Warren; Arthur W Zieske; Tomoo Iwakuma; Jay K Kolls; Yan Cui
Journal: FASEB J Date: 2011-04-06 Impact factor: 5.191

Review 5. A review of alcohol-pathogen interactions: New insights into combined disease pathomechanisms.

Authors: Natalia A Osna; Moses New-Aaron; Raghubendra S Dagur; Paul Thomes; Liz Simon; Danielle Levitt; Patrick McTernan; Patricia E Molina; Hye Yeon Choi; Keigo Machida; Kenneth E Sherman; Antonio Riva; Sandra Phillips; Shilpa Chokshi; Kusum K Kharbanda; Steven Weinman; Murali Ganesan
Journal: Alcohol Clin Exp Res Date: 2022-02-06 Impact factor: 3.455

p53: a new kingpin in the stem cell arena.

1. IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.

2. NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

3. MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

4. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.

Review 5. A review of alcohol-pathogen interactions: New insights into combined disease pathomechanisms.

Review 6. Psychiatric disorders biochemical pathways unraveled by human brain proteomics.

7. NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells.

8. p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.

9. Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors.

Review 10. Cell fate, metabolic reprogramming and lncRNA of tumor-initiating stem-like cells induced by alcohol.