Toba N Niazi1, Craig Forester, Zeinab Afify, Jay Riva-Cambrin. 1. Department of Neurosurgery, Primary Children's Medical Center, University of Utah, 100 N. Mario Capecchi Drive, Salt Lake, Utah 84113, USA. jay.riva-cambrin@hsc.utah.edu
Abstract
PURPOSE: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Brain metastasis from osteosarcoma was once uncommon; however, with the advent of chemotherapeutic agents and improved imaging modalities, it has become a more common and recognized finding. Brain metastases are, rarely, the initial presenting symptom, but instead are a late and preterminal event in the disease process. When osteosarcomas manifest in the central nervous system, they tend to occur in the gray-white junction in the anterior circulation akin to other metastatic lesions in the brain. CASE REPORT: The authors report a case of a 16-year-old boy who presented with acute neurological deterioration due to a posterior fossa hemorrhage and was subsequently found to have a primary site localizing to the metaphysis of the right femur with florid metastatic disease. CONCLUSIONS: This is the first case reported in the literature in which an osteosarcoma initially presented as cerebral metastasis in the form of a posterior fossa hemorrhage with a rapidly deteriorating course.
PURPOSE:Osteosarcoma is the most common malignant bone tumor in children and adolescents. Brain metastasis from osteosarcoma was once uncommon; however, with the advent of chemotherapeutic agents and improved imaging modalities, it has become a more common and recognized finding. Brain metastases are, rarely, the initial presenting symptom, but instead are a late and preterminal event in the disease process. When osteosarcomas manifest in the central nervous system, they tend to occur in the gray-white junction in the anterior circulation akin to other metastatic lesions in the brain. CASE REPORT: The authors report a case of a 16-year-old boy who presented with acute neurological deterioration due to a posterior fossa hemorrhage and was subsequently found to have a primary site localizing to the metaphysis of the right femur with florid metastatic disease. CONCLUSIONS: This is the first case reported in the literature in which an osteosarcoma initially presented as cerebral metastasis in the form of a posterior fossa hemorrhage with a rapidly deteriorating course.
Authors: María Tereza Nieto-Coronel; Allan David López-Vásquez; Diana Marroquín-Flores; Sandy Ruiz-Cruz; Jorge Luis Martínez-Tláhuel; Jaime De la Garza-Salazar Journal: Rep Pract Oncol Radiother Date: 2018-07-26