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Literature DB >> 19763305

A colorimetric and fluorescent merocyanine-based probe for biological thiols.

Shu-Ping Wang¹, Wu-Jian Deng, Dan Sun, Min Yan, Hong Zheng, Jin-Gou Xu.

Abstract

A new "dual-mode" chromogenic and fluorescent turn-on probe (2) for the selective sensing of biological thiols is reported. In MeOH-H(2)O cosolvent at physiological pH 7.40 (MeOH-H(2)O = 3:7), biological thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the chromo- and fluorophore merocyanine (3).

Entities: Chemical

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Year: 2009 PMID： 19763305 DOI： 10.1039/b909760k

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

12 in total

1. Conjugate addition/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine.

Authors: Xiaofeng Yang; Yixing Guo; Robert M Strongin
Journal: Angew Chem Int Ed Engl Date: 2011-09-20 Impact factor: 15.336

2. Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry.

Authors: Sadakatali S Gori; Pawel Lorkiewicz; Daniel S Ehringer; Alex C Belshoff; Richard M Higashi; Teresa W-M Fan; Michael H Nantz
Journal: Anal Bioanal Chem Date: 2014-05-25 Impact factor: 4.142

3. A fluorogenic probe for β-galactosidase activity imaging in living cells.

Authors: Junyan Han; Myung Shin Han; Ching-Hsuan Tung
Journal: Mol Biosyst Date: 2013-09-19

Review 4. Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.

Authors: Cai-Xia Yin; Kang-Ming Xiong; Fang-Jun Huo; James C Salamanca; Robert M Strongin
Journal: Angew Chem Int Ed Engl Date: 2017-09-22 Impact factor: 15.336

5. Stimuli-Responsive Polymer Film that Autonomously Translates a Molecular Detection Event into a Macroscopic Change in Its Optical Properties via a Continuous, Thiol-Mediated Self-Propagating Reaction.

Authors: Hemakesh Mohapatra; Hyungwoo Kim; Scott T Phillips
Journal: J Am Chem Soc Date: 2015-09-23 Impact factor: 15.419

6. High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe.

Authors: Megan M McCallum; Premchendar Nandhikonda; Jonathan J Temmer; Charles Eyermann; Anton Simeonov; Ajit Jadhav; Adam Yasgar; David Maloney; Alexander Leggy Arnold
Journal: J Biomol Screen Date: 2013-02-27

A colorimetric and fluorescent merocyanine-based probe for biological thiols.

1. Conjugate addition/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine.

2. Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry.

3. A fluorogenic probe for β-galactosidase activity imaging in living cells.

Review 4. Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.

5. Stimuli-Responsive Polymer Film that Autonomously Translates a Molecular Detection Event into a Macroscopic Change in Its Optical Properties via a Continuous, Thiol-Mediated Self-Propagating Reaction.

6. High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe.

7. Preparation of a conjugation-ready thiol responsive molecular switch.

8. A selective glutathione probe based on AIE fluorogen and its application in enzymatic activity assay.

9. Labelling Bacterial Nanocages with Photo-switchable Fluorophores.

Review 10. Thiol reactive probes and chemosensors.