Literature DB >> 19763117

The Coalition Against Major Diseases: developing tools for an integrated drug development process for Alzheimer's and Parkinson's diseases.

K Romero1, M de Mars, D Frank, M Anthony, J Neville, L Kirby, K Smith, R L Woosley.   

Abstract

Aiming to emulate the successful accelerated development of HIV/AIDS drugs, the Critical Path Institute (C-Path), in collaboration with the Engelberg Center for Health Care Reform at the Brookings Institution, has formed the Coalition Against Major Diseases (CAMD). Members include 6 nonprofit groups representing patients' interests, 15 leading pharmaceutical companies, the US Food and Drug Administration (FDA), the European Medicines Agency (EMEA), 2 institutes of the National Institutes of Health (NIH)-the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS)-and representatives from academia. The coalition's purpose is to transform the drug development paradigm for neurodegenerative diseases and serve as a model for other major diseases.

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Year:  2009        PMID: 19763117     DOI: 10.1038/clpt.2009.165

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  17 in total

1.  Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.

Authors:  Robert Küffner; Neta Zach; Raquel Norel; Johann Hawe; David Schoenfeld; Liuxia Wang; Guang Li; Lilly Fang; Lester Mackey; Orla Hardiman; Merit Cudkowicz; Alexander Sherman; Gokhan Ertaylan; Moritz Grosse-Wentrup; Torsten Hothorn; Jules van Ligtenberg; Jakob H Macke; Timm Meyer; Bernhard Schölkopf; Linh Tran; Rubio Vaughan; Gustavo Stolovitzky; Melanie L Leitner
Journal:  Nat Biotechnol       Date:  2014-11-02       Impact factor: 54.908

2.  The future is now: model-based clinical trial design for Alzheimer's disease.

Authors:  K Romero; K Ito; J A Rogers; D Polhamus; R Qiu; D Stephenson; R Mohs; R Lalonde; V Sinha; Y Wang; D Brown; M Isaac; S Vamvakas; R Hemmings; L Pani; L J Bain; B Corrigan
Journal:  Clin Pharmacol Ther       Date:  2014-12-27       Impact factor: 6.875

3.  Optimizing disease progression study designs for drug effect discrimination.

Authors:  Sebastian Ueckert; Stefanie Hennig; Joakim Nyberg; Mats O Karlsson; Andrew C Hooker
Journal:  J Pharmacokinet Pharmacodyn       Date:  2013-08-27       Impact factor: 2.745

4.  Brain and disease: the long path to discovery and treatment.

Authors:  S L Miksys; R F Tyndale
Journal:  Clin Pharmacol Ther       Date:  2009-10       Impact factor: 6.875

5.  Counterpoint: Do not opine before it's time.

Authors:  Isaac S Kohane; David M Margulies
Journal:  Nat Biotechnol       Date:  2011-03       Impact factor: 54.908

6.  Point: Are we prepared for the future doctor visit?

Authors:  Stephen H Friend; Trey Ideker
Journal:  Nat Biotechnol       Date:  2011-03       Impact factor: 54.908

7.  Combining patient-level and summary-level data for Alzheimer's disease modeling and simulation: a β regression meta-analysis.

Authors:  James A Rogers; Daniel Polhamus; William R Gillespie; Kaori Ito; Klaus Romero; Ruolun Qiu; Diane Stephenson; Marc R Gastonguay; Brian Corrigan
Journal:  J Pharmacokinet Pharmacodyn       Date:  2012-07-21       Impact factor: 2.745

8.  Elements for adequate informed consent in the surgical context.

Authors:  Hernando Abaunza; Klaus Romero
Journal:  World J Surg       Date:  2014-07       Impact factor: 3.352

9.  Sex-specific patterns and differences in dementia and Alzheimer's disease using informatics approaches.

Authors:  Jay Geronimo Ronquillo; Merritt Rachel Baer; William T Lester
Journal:  J Women Aging       Date:  2016-04-22

Review 10.  The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Authors:  Adam L Boxer; Michael Gold; Edward Huey; William T Hu; Howard Rosen; Joel Kramer; Fen-Biao Gao; Edward A Burton; Tiffany Chow; Aimee Kao; Blair R Leavitt; Bruce Lamb; Megan Grether; David Knopman; Nigel J Cairns; Ian R Mackenzie; Laura Mitic; Erik D Roberson; Daniel Van Kammen; Marc Cantillon; Kathleen Zahs; George Jackson; Stephen Salloway; John Morris; Gary Tong; Howard Feldman; Howard Fillit; Susan Dickinson; Zaven S Khachaturian; Margaret Sutherland; Susan Abushakra; Joseph Lewcock; Robert Farese; Robert O Kenet; Frank Laferla; Steve Perrin; Steve Whitaker; Lawrence Honig; Marsel M Mesulam; Brad Boeve; Murray Grossman; Bruce L Miller; Jeffrey L Cummings
Journal:  Alzheimers Dement       Date:  2012-10-10       Impact factor: 21.566

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