Hilde K Brekke1, Johnny Ludvigsson. 1. Department of Clinical Nutrition, Sahlgrenska Academy at Göteborg University, 405 30 Göteborg, Sweden. hilde.brekke@nutrition.gu.se
Abstract
OBJECTIVE: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers' diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr of age. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); tyrosine phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. The 5 724 children in whom we carried out two to three possible blood samplings were included in the study. Logistic regression analysis was used to identify variables predicting IA. RESULTS: Of 5 724 children,191 (3.3%) were considered positive for IA. In a univariate analysis, less than daily consumption of vegetables (3-5 times/week) in the mothers' diet was associated with increased risk of IA (OR 1.71, 95% CI:1.24-2.35, p = 0.001) compared to daily consumption (p for trend = 0.004). The association was strengthened when adjusting for known IA-risk factors (p for trend <0.001). CONCLUSIONS: Daily consumption of vegetables in the mothers' diet during pregnancy was associated with a decreased risk of IA in the offspring.
OBJECTIVE: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers' diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr of age. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); tyrosine phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. The 5 724 children in whom we carried out two to three possible blood samplings were included in the study. Logistic regression analysis was used to identify variables predicting IA. RESULTS: Of 5 724 children,191 (3.3%) were considered positive for IA. In a univariate analysis, less than daily consumption of vegetables (3-5 times/week) in the mothers' diet was associated with increased risk of IA (OR 1.71, 95% CI:1.24-2.35, p = 0.001) compared to daily consumption (p for trend = 0.004). The association was strengthened when adjusting for known IA-risk factors (p for trend <0.001). CONCLUSIONS: Daily consumption of vegetables in the mothers' diet during pregnancy was associated with a decreased risk of IA in the offspring.
Authors: Randi K Johnson; Roy Tamura; Nicole Frank; Ulla Uusitalo; Jimin Yang; Sari Niinistö; Carin Andrén Aronsson; Anette-G Ziegler; William Hagopian; Marian Rewers; Jorma Toppari; Beena Akolkar; Jeffrey Krischer; Suvi M Virtanen; Jill M Norris Journal: Diabetologia Date: 2021-03-30 Impact factor: 10.460
Authors: Danielle J Borg; Felicia Y T Yap; Sahar Keshvari; David G Simmons; Linda A Gallo; Amelia K Fotheringham; Aowen Zhuang; Robyn M Slattery; Sumaira Z Hasnain; Melinda T Coughlan; Phillip Kantharidis; Josephine M Forbes Journal: Islets Date: 2017-12-22 Impact factor: 2.694