Matt Sagransky1, Brad A Yentzer, Steven R Feldman. 1. Department of Dermatology, Wake Forest University School of Medicine, Center for Dermatology Research, Winston-Salem, NC 27157-1071, USA.
Abstract
BACKGROUND: Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris. OBJECTIVE: This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO. METHODS: A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and combination therapy. RESULTS: BPO is equally effective at concentrations of 2.5, 5.0 and 10%. However, a concentration-dependent irritant dermatitis can occur with higher concentrations. The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines. BPO-containing combinations do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.
BACKGROUND: Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris. OBJECTIVE: This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO. METHODS: A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and combination therapy. RESULTS:BPO is equally effective at concentrations of 2.5, 5.0 and 10%. However, a concentration-dependent irritant dermatitis can occur with higher concentrations. The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines. BPO-containing combinations do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.
Authors: Azmy Ahmed Abd El-Latif; Faisal Abdel Aziz Hassan; Ahmed Rashad Elshahed; Amr Ghareeb Mohamed; Mohamed L Elsaie Journal: Lasers Med Sci Date: 2013-10-10 Impact factor: 3.161