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Literature DB >> 1976101

Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping.

D Jenkins¹, C Mijovic, J Fletcher, K H Jacobs, A R Bradwell, A H Barnett.

Abstract

A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome. Recombinant DNA technology and trans-racial studies have been used to allow finer mapping of genetic predisposition to Type 1 diabetes. These techniques have localised alleles encoding susceptibility and resistance to the DQ region. Other alleles determining disease susceptibility remain poorly localised.

Entities: Disease

Mesh：

Year: 1990 PMID： 1976101 DOI： 10.1007/bf00404086

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

68 in total

1. Primary association of HLA-DQw8 with type I diabetes in DR4 patients.

Authors: D Owerbach; S Gunn; K H Gabbay
Journal: Diabetes Date: 1989-07 Impact factor: 9.461

2. HLA-DR3, DQ heterogeneity in American blacks is associated with susceptibility and resistance to insulin dependent diabetes mellitus.

Authors: G M Dunston; L W Henry; J Christian; M D Ofosu; C O Callender
Journal: Transplant Proc Date: 1989-02 Impact factor: 1.066

3. Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

Authors: S J Kim; S L Holbeck; B Nisperos; J A Hansen; H Maeda; G T Nepom
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205

4. Three-allele synergistic mixed model for insulin-dependent diabetes mellitus.

Authors: E J Louis; G Thomson
Journal: Diabetes Date: 1986-09 Impact factor: 9.461

Review 5. Genetics and polymorphism: class II antigens.

Authors: J Trowsdale
Journal: Br Med Bull Date: 1987-01 Impact factor: 4.291

6. Insulin-dependent diabetes mellitus: HLA-DR and -DQ genotyping in three ethnic groups.

Authors: M R Kohonen-Corish; S W Serjeantson; H K Lee; P Zimmet
Journal: Dis Markers Date: 1987-09 Impact factor: 3.434

7. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.

Authors: P A Morel; J S Dorman; J A Todd; H O McDevitt; M Trucco
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

8. HLA-A, B, C and DR antigens in young South African blacks with Type 1 (insulin-dependent) diabetes mellitus.

Authors: M A Omar; M G Hammond; A C Asmal
Journal: Diabetologia Date: 1984-01 Impact factor: 10.122

9. The prevalence of islet cell antibodies in Japanese insulin-dependent and non-insulin-dependent diabetic patients studied by indirect immunofluorescence and by a new method.

Authors: T Kobayashi; T Sugimoto; T Itoh; K Kosaka; T Tanaka; S Suwa; K Sato; K Tsuji
Journal: Diabetes Date: 1986-03 Impact factor: 9.461

10. The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.

Authors: J A Todd; Y Fukui; T Kitagawa; T Sasazuki
Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

13 in total

1. Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.

Authors: D Jenkins; M A Penny; Y Uchigata; K H Jacobs; C H Mijovic; Y Hirata; T Otani; J Fletcher; A R Bradwell; A H Barnett
Journal: Am J Hum Genet Date: 1992-05 Impact factor: 11.025

Review 2. Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders.

Authors: Akane Ide; George S Eisenbarth
Journal: Rev Endocr Metab Disord Date: 2003-09 Impact factor: 6.514

Review 3. The genetics of type I (insulin dependent) diabetes mellitus.

Authors: D Cavan; S Bain; A Barnett
Journal: J Med Genet Date: 1992-07 Impact factor: 6.318

4. DRB genotyping supports recessive inheritance of DR3-associated susceptibility to insulin-dependent diabetes mellitus.

Authors: D Jenkins; J Fletcher; M A Penny; C H Mijovic; K H Jacobs; A R Bradwell; A H Barnett
Journal: Am J Hum Genet Date: 1991-07 Impact factor: 11.025

5. Detecting disease-predisposing variants: the haplotype method.

Authors: A M Valdes; G Thomson
Journal: Am J Hum Genet Date: 1997-03 Impact factor: 11.025

Review 6. Strategies for preventing type I diabetes mellitus.

Authors: C F Verge; G S Eisenbarth
Journal: West J Med Date: 1996-03

7. Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus.

Authors: D Jenkins; M A Penny; C H Mijovic; K H Jacobs; J Fletcher; A H Barnett
Journal: Diabetologia Date: 1991-08 Impact factor: 10.122

8. Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243.

Authors: T Kobayashi; Y Oka; H Katagiri; A Falorni; A Kasuga; I Takei; K Nakanishi; T Murase; K Kosaka; A Lernmark
Journal: Diabetologia Date: 1996-10 Impact factor: 10.122

9. Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.

Authors: D Jenkins; C Mijovic; K H Jacobs; M A Penny; J Fletcher; A H Barnett
Journal: Diabetologia Date: 1991-02 Impact factor: 10.122

10. HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.

Authors: I Kockum; R Wassmuth; E Holmberg; B Michelsen; A Lernmark
Journal: Am J Hum Genet Date: 1993-07 Impact factor: 11.025