Literature DB >> 2786821

Primary association of HLA-DQw8 with type I diabetes in DR4 patients.

D Owerbach1, S Gunn, K H Gabbay.   

Abstract

DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain reaction technique for HLA-DR4 and the associated Dw and DQB subtypes of DR4. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Dw subtypes of DR4 other than DW10 did not confer additional association with type I diabetes. Thus, the DQ region appears to provide the primary major histocompatibility association with type I diabetes in most DR4 patients.

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Year:  1989        PMID： 2786821     DOI： 10.2337/diab.38.7.942

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  12 in total

Review 1.  Genetic predisposition to IDDM.

Authors:  S Caillat-Zucman; J F Bach
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

Review 2.  Genetic analysis of susceptibility to type 1 diabetes.

Authors:  J A Todd
Journal:  Springer Semin Immunopathol       Date:  1992

3.  The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

Authors:  J A Noble; A M Valdes; M Cook; W Klitz; G Thomson; H A Erlich
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

4.  Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.

Authors:  D Jenkins; C Mijovic; K H Jacobs; M A Penny; J Fletcher; A H Barnett
Journal:  Diabetologia       Date:  1991-02       Impact factor: 10.122

5.  Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma).

Authors:  J D Reveille; D Owerbach; R Goldstein; R Moreda; R A Isern; F C Arnett
Journal:  J Clin Invest       Date:  1992-04       Impact factor: 14.808

6.  Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype.

Authors:  Xiaomin Wen; Junbao Yang; Eddie James; I-Ting Chow; Helena Reijonen; William W Kwok
Journal:  Sci Immunol       Date:  2020-02-14

7.  HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.

Authors:  I Kockum; R Wassmuth; E Holmberg; B Michelsen; A Lernmark
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025

Review 8.  Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.

Authors:  E Thorsby; K S Rønningen
Journal:  Diabetologia       Date:  1993-05       Impact factor: 10.122

9.  The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.

Authors:  J A Todd; Y Fukui; T Kitagawa; T Sasazuki
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

Review 10.  Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping.

Authors:  D Jenkins; C Mijovic; J Fletcher; K H Jacobs; A R Bradwell; A H Barnett
Journal:  Diabetologia       Date:  1990-07       Impact factor: 10.122
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