BACKGROUND/AIMS: KL-6 mucin is MUC1 bearing sialylated carbohydrate epitopes recognized by KL-6 antibody. This study aimed to assess subcellular localization of KL-6 mucin in liver metastatic tissues from colorectal carcinoma and hepatocellular carcinoma tissues. METHODOLOGY: Tissue samples were collected from 56 patients with liver metastasis of colorectal carcinoma and 92 patients with hepatocellular carcinoma who underwent a hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: All 56 cases with metastatic liver cancer showed positive staining for KL-6 mucin in cancer tissues but not in non-cancerous tissues. All staining was observed in the circumferential membrane and/or cytoplasm of the cancer cells. In contrast, no staining for KL-6 mucin was observed in either cancerous or non-cancerous tissues of the 92 patients with hepatocellular carcinoma. CONCLUSIONS: KL-6 mucin may be an indicator for liver metastasis of colorectal carcinoma. Additionally, detection of KL-6 mucin may be helpful in distinguishing hepatocellular carcinoma from metastatic liver cancer.
BACKGROUND/AIMS: KL-6 mucin is MUC1 bearing sialylated carbohydrate epitopes recognized by KL-6 antibody. This study aimed to assess subcellular localization of KL-6 mucin in liver metastatic tissues from colorectal carcinoma and hepatocellular carcinoma tissues. METHODOLOGY: Tissue samples were collected from 56 patients with liver metastasis of colorectal carcinoma and 92 patients with hepatocellular carcinoma who underwent a hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: All 56 cases with metastatic liver cancer showed positive staining for KL-6 mucin in cancer tissues but not in non-cancerous tissues. All staining was observed in the circumferential membrane and/or cytoplasm of the cancer cells. In contrast, no staining for KL-6 mucin was observed in either cancerous or non-cancerous tissues of the 92 patients with hepatocellular carcinoma. CONCLUSIONS:KL-6 mucin may be an indicator for liver metastasis of colorectal carcinoma. Additionally, detection of KL-6 mucin may be helpful in distinguishing hepatocellular carcinoma from metastatic liver cancer.
Authors: Carl Christoph Schimanski; Markus Möhler; Michael Schön; Eric van Cutsem; Richard Greil; Wolf Otto Bechstein; Susanna Hegewisch-Becker; Götz von Wichert; Matthias Vöhringer; Michael Heike; Volker Heinemann; Marc Peeters; Stephan Kanzler; Stefan Kasper; Friedrich Overkamp; Jan Schröder; Daniel Seehofer; Frank Kullmann; Bernhard Linz; Irene Schmidtmann; Victoria Smith-Machnow; Ines Gockel; Hauke Lang; Peter R Galle Journal: BMC Cancer Date: 2012-04-11 Impact factor: 4.430
Authors: Carl Christoph Schimanski; Stefan Kasper; Susanna Hegewisch-Becker; Jan Schröder; Friedrich Overkamp; Frank Kullmann; Wolf Otto Bechstein; Matthias Vöhringer; Robert Öllinger; Florian Lordick; Volker Heinemann; Michael Geißler; Armin Schulz-Abelius; Helga Bernhard; Michael R Schön; Richard Greil; Peter Galle; Hauke Lang; Irene Schmidtmann; Markus Moehler Journal: Oncoimmunology Date: 2020-08-23 Impact factor: 8.110