Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 HTR2A gene variation is involved in antidepressant treatment response.

Literature DB >> 19758789

HTR2A gene variation is involved in antidepressant treatment response.

Susanne Lucae¹, Marcus Ising, Sonja Horstmann, Bernhard T Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschke.

Abstract

Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2010 PMID： 19758789 DOI： 10.1016/j.euroneuro.2009.08.006

Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600

Keyword Cloud
Cited

18 in total

Review 1. Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications.

Authors: Chiara Fabbri; Alessandro Serretti
Journal: Curr Psychiatry Rep Date: 2015-07 Impact factor: 5.285

Review 2. Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.

Authors: Tristram A Lett; Henrik Walter; Eva J Brandl
Journal: CNS Drugs Date: 2016-12 Impact factor: 5.749

3. Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response.

Authors: Karen Hodgson; Shaista Jeelani Mufti; Rudolf Uher; Peter McGuffin
Journal: Genome Med Date: 2012-06-27 Impact factor: 11.117

Review 4. Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years.

Authors: G Voegeli; M L Cléry-Melin; N Ramoz; P Gorwood
Journal: Drugs Date: 2017-12 Impact factor: 9.546

Review 5. Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks.

Authors: Bharathi S Gadad; Manish K Jha; Andrew Czysz; Jennifer L Furman; Taryn L Mayes; Michael P Emslie; Madhukar H Trivedi
Journal: J Affect Disord Date: 2017-07-05 Impact factor: 4.839

6. 5-HT₂A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system.

Authors: G Quesseveur; C Repérant; D J David; A M Gardier; C Sanchez; B P Guiard
Journal: Exp Brain Res Date: 2013-02-15 Impact factor: 1.972

HTR2A gene variation is involved in antidepressant treatment response.

Review 1. Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications.

Review 2. Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.

3. Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response.

Review 4. Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years.

Review 5. Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks.

6. 5-HT₂A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system.

Review 7. Pharmacogenomic Testing in Child and Adolescent Psychiatry: An Evidence-Based Review.

8. Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.

9. Race, genetic ancestry and response to antidepressant treatment for major depression.

10. Epigenetic Modulation of Mood Disorders.