Thomas Herrmann1, Claudia Günther, Peter Csere. 1. Department of Radiotherapy and Radiooncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstrasse 74, Dresden, Germany. thomas.herrmann@mailbox.tu-dresden.de
Abstract
UNLABELLED: PURPOSE AND APPROACH: To report a case of morphea (localized scleroderma) in a patient following breast cancer therapy and to summarize the current literature. RESULTS AND CONCLUSION: The occurrence of morphea is an unexpected late effect (approximately 1 year after the end of radiation therapy) which occurs frequently in the irradiated breast in women with breast-conserving therapy. The pathogenesis is unclear. The main differential diagnoses are recurrence of carcinoma and a radiogenic subcutaneous fibrosis (in most cases, the final diagnosis can only be made by means of a biopsy). Diagnosis and therapy must be performed in cooperation between dermatologist and radiooncologist.
UNLABELLED: PURPOSE AND APPROACH: To report a case of morphea (localized scleroderma) in a patient following breast cancer therapy and to summarize the current literature. RESULTS AND CONCLUSION: The occurrence of morphea is an unexpected late effect (approximately 1 year after the end of radiation therapy) which occurs frequently in the irradiated breast in women with breast-conserving therapy. The pathogenesis is unclear. The main differential diagnoses are recurrence of carcinoma and a radiogenic subcutaneous fibrosis (in most cases, the final diagnosis can only be made by means of a biopsy). Diagnosis and therapy must be performed in cooperation between dermatologist and radiooncologist.
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