Literature DB >> 19754401

The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease.

Jia Li1, John A Dani, Weidong Le.   

Abstract

Parkinson's disease (PD) is characterized by the selective loss of dopamine (DA) neurons in the substantia nigra compacta (SNc). The transcription factor Pitx3 is important for the differentiation and maintenance of midbrain DA neurons during development. There is highly restricted and constitutive expression of Pitx3 in the SNc and ventral tegmental area (VTA) of the midbrain after birth. In addition to its importance during development, Pitx3 also has roles in the long-term survival and maintenance of the midbrain DA neurons. In this review, we discuss the function of Pitx3 throughout the life of midbrain neurons and the contribution of Pitx3 to disease mechanisms.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19754401      PMCID： PMC2872921     

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  41 in total

1.  Molecular biology. Glimpses of a tiny RNA world.

Authors:  G Ruvkun
Journal:  Science       Date:  2001-10-26       Impact factor: 47.728

2.  Pitx3 is required for development of substantia nigra dopaminergic neurons.

Authors:  Irene Nunes; Lucy T Tovmasian; Robert M Silva; Robert E Burke; Stephen P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-24       Impact factor: 11.205

3.  PITX3 polymorphism is associated with early onset Parkinson's disease.

Authors:  Olle Bergman; Anna Håkansson; Lars Westberg; Kajsa Nordenström; Andrea Carmine Belin; Olof Sydow; Lars Olson; Björn Holmberg; Elias Eriksson; Hans Nissbrandt
Journal:  Neurobiol Aging       Date:  2008-04-16       Impact factor: 4.673

4.  A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice.

Authors:  D K Rieger; E Reichenberger; W McLean; A Sidow; B R Olsen
Journal:  Genomics       Date:  2001-02-15       Impact factor: 5.736

5.  A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter.

Authors:  P Cazorla; M P Smidt; K L O'Malley; J P Burbach
Journal:  J Neurochem       Date:  2000-05       Impact factor: 5.372

6.  Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site.

Authors:  M Lebel; Y Gauthier; A Moreau; J Drouin
Journal:  J Neurochem       Date:  2001-04       Impact factor: 5.372

7.  BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization.

Authors:  O Guillin; J Diaz; P Carroll; N Griffon; J C Schwartz; P Sokoloff
Journal:  Nature       Date:  2001-05-03       Impact factor: 49.962

8.  Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice.

Authors:  E V Semina; J C Murray; R Reiter; R F Hrstka; J Graw
Journal:  Hum Mol Genet       Date:  2000-07-01       Impact factor: 6.150

Review 9.  Transcriptional control of dopamine neuron development.

Authors:  Asa Wallén; Thomas Perlmann
Journal:  Ann N Y Acad Sci       Date:  2003-06       Impact factor: 5.691

Review 10.  Sonic hedgehog in the nervous system: functions, modifications and mechanisms.

Authors:  Karen S Ho; Matthew P Scott
Journal:  Curr Opin Neurobiol       Date:  2002-02       Impact factor: 6.627
View more
  23 in total

1.  Pigmy MicroRNA: surveillance cops in Therapies kingdom.

Authors:  Utpal Bhadra; Pradipta Patra; Jagamohan Chhatai; Manika Pal-Bhadra
Journal:  Mol Med       Date:  2016-09-28       Impact factor: 6.354

2.  Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease.

Authors:  Dilshan S Harischandra; Dharmin Rokad; Shivani Ghaisas; Saurabh Verma; Alan Robertson; Huajun Jin; Vellareddy Anantharam; Arthi Kanthasamy; Anumantha G Kanthasamy
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-08-20       Impact factor: 5.187

3.  Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson's Disease in Mouse Midbrain.

Authors:  Joseph Kochmanski; Sarah E VanOeveren; Joseph R Patterson; Alison I Bernstein
Journal:  Toxicol Sci       Date:  2019-06-01       Impact factor: 4.849

Review 4.  Animal models of Parkinson's disease: a gateway to therapeutics?

Authors:  Weidong Le; Pavani Sayana; Joseph Jankovic
Journal:  Neurotherapeutics       Date:  2014-01       Impact factor: 7.620

Review 5.  Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.

Authors:  Katherine E Squires; Carolina Montañez-Miranda; Rushika R Pandya; Matthew P Torres; John R Hepler
Journal:  Pharmacol Rev       Date:  2018-07       Impact factor: 25.468

Review 6.  Deciphering transcription dysregulation in FSH muscular dystrophy.

Authors:  Melanie Ehrlich; Michelle Lacey
Journal:  J Hum Genet       Date:  2012-06-21       Impact factor: 3.172

Review 7.  Emerging roles of epigenetic mechanisms in Parkinson's disease.

Authors:  Ehsan Habibi; Ali Masoudi-Nejad; Hamid Mostafavi Abdolmaleky; Stephen J Haggarty
Journal:  Funct Integr Genomics       Date:  2011-09-04       Impact factor: 3.410

8.  Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.

Authors:  Gale A Kleven; Priyanka Joshi; Marco Voogd; April E Ronca
Journal:  Eur J Neurosci       Date:  2013-03-13       Impact factor: 3.386

9.  Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice.

Authors:  Weidong Le; Lifen Zhang; Wenjie Xie; Song Li; John A Dani
Journal:  Neurobiol Aging       Date:  2015-08-20       Impact factor: 4.673

Review 10.  Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection.

Authors:  Aida Nasirishargh; Priyadarsini Kumar; Lalithasri Ramasubramanian; Kaitlin Clark; Dake Hao; Sabrina V Lazar; Aijun Wang
Journal:  World J Stem Cells       Date:  2021-07-26       Impact factor: 5.326
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.