Literature DB >> 11861165

Sonic hedgehog in the nervous system: functions, modifications and mechanisms.

Karen S Ho1, Matthew P Scott.   

Abstract

Signaling by Sonic hedgehog (Shh) controls important developmental processes, including dorsoventral neural tube patterning, neural stem cell proliferation, and neuronal and glial cell survival. Shh signaling involves lipid modifications to Shh itself, as well as changes in protein subcellular localization. Recent advances have revealed the importance of palmitoylation and acylation of Shh on its potency and migration capacity. Subsequent trafficking and organelle sorting in the Shh signaling pathway have been observed; these observations offer a new dimension to our understanding of downstream signal transduction events.

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Year:  2002        PMID： 11861165     DOI： 10.1016/s0959-4388(02)00290-8

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  48 in total

1.  The sonic hedgehog signaling system as a bistable genetic switch.

Authors:  Karen Lai; Matthew J Robertson; David V Schaffer
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

2.  The complex nature of constitutional de novo apparently balanced translocations in patients presenting with abnormal phenotypes.

Authors:  S M Gribble; E Prigmore; D C Burford; K M Porter; Bee Ling Ng; E J Douglas; H Fiegler; P Carr; D Kalaitzopoulos; S Clegg; R Sandstrom; I K Temple; S A Youings; N S Thomas; N R Dennis; P A Jacobs; J A Crolla; N P Carter
Journal:  J Med Genet       Date:  2005-01       Impact factor: 6.318

Review 3.  Intraretinal projection of retinal ganglion cell axons as a model system for studying axon navigation.

Authors:  Zheng-Zheng Bao
Journal:  Brain Res       Date:  2007-02-02       Impact factor: 3.252

4.  Genetic analyses demonstrate that bone morphogenetic protein signaling is required for embryonic cerebellar development.

Authors:  Lihua Qin; Lara Wine-Lee; Kyung J Ahn; E Bryan Crenshaw
Journal:  J Neurosci       Date:  2006-02-15       Impact factor: 6.167

Review 5.  The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease.

Authors:  Jia Li; John A Dani; Weidong Le
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

6.  Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures.

Authors:  Megumi Hirose; Pawel Niewiadomski; Gary Tse; Gloria C Chi; Hongmei Dong; Alice Lee; Ellen M Carpenter; James A Waschek
Journal:  J Neurosci Res       Date:  2011-06-14       Impact factor: 4.164

7.  Expression pattern of sonic hedgehog and effect of topical mitomycin C on its expression in human ocular surface neoplasms.

Authors:  Kyoko Fujita; Takeshi Miyamoto; Yuka Okada; Nobuyuki Ishikawa; Shizuya Saika
Journal:  Jpn J Ophthalmol       Date:  2008-07-27       Impact factor: 2.447

8.  Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.

Authors:  Miao-Hsueh Chen; Ya-Jun Li; Takatoshi Kawakami; Shan-Mei Xu; Pao-Tien Chuang
Journal:  Genes Dev       Date:  2004-03-15       Impact factor: 11.361

9.  c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice.

Authors:  Ganesh Rao; Carolyn A Pedone; Cheryl M Coffin; Eric C Holland; Daniel W Fults
Journal:  Neoplasia       Date:  2003 May-Jun       Impact factor: 5.715

10.  Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog.

Authors:  John A Buglino; Marilyn D Resh
Journal:  PLoS One       Date:  2010-06-23       Impact factor: 3.240
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