Literature DB >> 19753350

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles.

Vincent J Venditto1, Kimberly Allred, Clinton D Allred, Eric E Simanek.   

Abstract

The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

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Year:  2009        PMID： 19753350      PMCID： PMC3881288          DOI： 10.1039/b911353c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  37 in total

1.  Chemoselective building blocks for dendrimers from relative reactivity data.

Authors:  Mackay B Steffensen; Eric E Simanek
Journal:  Org Lett       Date:  2003-06-26       Impact factor: 6.005

2.  Dendritic supramolecular assemblies for drug delivery.

Authors:  Meredith T Morgan; Michael A Carnahan; Stella Finkelstein; Carla A H Prata; Lovorka Degoricija; Stephen J Lee; Mark W Grinstaff
Journal:  Chem Commun (Camb)       Date:  2005-07-14       Impact factor: 6.222

3.  20-O-acylcamptothecin derivatives: evidence for lactone stabilization.

Authors:  H Zhao; C Lee; P Sai; Y H Choe; M Boro; A Pendri; S Guan; R B Greenwald
Journal:  J Org Chem       Date:  2000-07-28       Impact factor: 4.354

4.  Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib.

Authors:  K Mross; S Steinbild; F Baas; D Gmehling; M Radtke; D Voliotis; E Brendel; O Christensen; C Unger
Journal:  Eur J Cancer       Date:  2006-11-13       Impact factor: 9.162

5.  Synthesis of linear, beta-cyclodextrin-based polymers and their camptothecin conjugates.

Authors:  Jianjun Cheng; Kay T Khin; Gregory S Jensen; Aijie Liu; Mark E Davis
Journal:  Bioconjug Chem       Date:  2003 Sep-Oct       Impact factor: 4.774

6.  SYNTHESIS OF 2-[3,3'-DI-(TERT-BUTOXYCARBONYL)-AMINODIPROPYLAMINE]-4,6,-DICHLORO-1,3,5-TRIAZINE AS A MONOMER AND 1,3,5-[TRIS-PIPERAZINE]-TRIAZINE AS A CORE FOR THE LARGE SCALE SYNTHESIS OF MELAMINE (TRIAZINE) DENDRIMERS.

Authors:  Abdellatif Chouai; Vincent J Venditto; Eric E Simanek; Ruth E McDermott; John A Ragan
Journal:  Organic Synth       Date:  2009-01-01

Review 7.  In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery.

Authors:  Michael F Neerman; Wen Zhang; Alan R Parrish; Eric E Simanek
Journal:  Int J Pharm       Date:  2004-08-20       Impact factor: 5.875

8.  Phase 2 study of intraperitoneal topotecan as consolidation chemotherapy in ovarian and primary peritoneal carcinoma.

Authors:  Howard G Muntz; Thomas W Malpass; Kathryn F McGonigle; Mandy D Robertson; Paul L Weiden
Journal:  Cancer       Date:  2008-08-01       Impact factor: 6.860

9.  Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil.

Authors:  Kristiane Haug; K Liza Kravik; Paula M De Angelis
Journal:  Anticancer Res       Date:  2008 Mar-Apr       Impact factor: 2.480

10.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Authors:  Y Matsumura; H Maeda
Journal:  Cancer Res       Date:  1986-12       Impact factor: 12.701
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  6 in total

1.  Multifunctional trackable dendritic scaffolds and delivery agents.

Authors:  Roey J Amir; Lorenzo Albertazzi; Jenny Willis; Anzar Khan; Taegon Kang; Craig J Hawker
Journal:  Angew Chem Int Ed Engl       Date:  2011-03-09       Impact factor: 15.336

2.  Biological assessment of triazine dendrimer: toxicological profiles, solution behavior, biodistribution, drug release and efficacy in a PEGylated, paclitaxel construct.

Authors:  Su-Tang Lo; Stephan Stern; Jeffrey D Clogston; Jiwen Zheng; Pavan P Adiseshaiah; Marina Dobrovolskaia; Jongdoo Lim; Anil K Patri; Xiankai Sun; Eric E Simanek
Journal:  Mol Pharm       Date:  2010-08-02       Impact factor: 4.939

3.  Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups.

Authors:  Jongdoo Lim; Vincent J Venditto; Eric E Simanek
Journal:  Bioorg Med Chem       Date:  2010-05-20       Impact factor: 3.641

4.  Divergent synthesis of triazine dendrimers using a trimethylene-dipiperidine linker that increases efficiency, simplifies analysis, and improves product solubility.

Authors:  Meredith A Mintzer; Lisa M Perez; Eric E Simanek
Journal:  Tetrahedron Lett       Date:  2010-03-31       Impact factor: 2.415

5.  Dendrimers terminated with dichlorotriazine groups provide a route to compositional diversity.

Authors:  Subrata Patra; Brittany Kozura; Adela Y-T Huang; Alan E Enciso; Xiankai Sun; Jer-Tsong Hsieh; Chai-Lin Kao; Hui-Ting Chen; Eric E Simanek
Journal:  Org Lett       Date:  2013-07-19       Impact factor: 6.005

Review 6.  Cancer therapies utilizing the camptothecins: a review of the in vivo literature.

Authors:  Vincent J Venditto; Eric E Simanek
Journal:  Mol Pharm       Date:  2010-04-05       Impact factor: 4.939
  6 in total

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