Literature DB >> 19753345

Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol.

Neil Vasdev1, Jason Chio, Erik M van Oosten, Mark Nitz, Joanne McLaurin, Douglass C Vines, Sylvain Houle, Raymond M Reilly, Alan A Wilson.   

Abstract

A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

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Year:  2009        PMID： 19753345     DOI： 10.1039/b913317h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Authors:  Mark P Thomas; Stephen J Mills; Barry V L Potter
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-22       Impact factor: 15.336

2.  Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors.

Authors:  J E Shaw; J Chio; S Dasgupta; A Y Lai; G C H Mo; F Pang; L A M Thomason; A J Yang; C M Yip; M Nitz; J McLaurin
Journal:  ACS Chem Neurosci       Date:  2011-12-23       Impact factor: 4.418

3.  Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models.

Authors:  Thimmappa S Anekonda; Teri L Wadsworth; Robert Sabin; Kate Frahler; Christopher Harris; Babett Petriko; Martina Ralle; Randy Woltjer; Joseph F Quinn
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

4.  H HRMAS NMR Derived Bio-markers Related to Tumor Grade, Tumor Cell Fraction, and Cell Proliferation in Prostate Tissue Samples.

Authors:  Katarina Stenman; Pär Stattin; Hans Stenlund; Katrine Riklund; Gerhard Gröbner; Anders Bergh
Journal:  Biomark Insights       Date:  2011-03-14

5.  (E)-2-(2-Methyl-cyclo-hexyl-idene)hydrazinecarbothio-amide.

Authors:  Justin W Hicks; Alan J Lough; Alan A Wilson; Neil Vasdev
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-22
  5 in total

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