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Literature DB >> 19752276

In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and vancomycin.

Cédric Jacqueline¹, Jocelyne Caillon, Virginie Le Mabecque, Anne-Françoise Miègeville, Yigong Ge, Donald Biek, Eric Batard, Gilles Potel.

Abstract

We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcus faecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates of E. faecalis.

Entities: Chemical Disease Species

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Year: 2009 PMID： 19752276 PMCID： PMC2786336 DOI： 10.1128/AAC.00984-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Evaluation of PPI-0903M (T91825), a novel cephalosporin: bactericidal activity, effects of modifying in vitro testing parameters and optimization of disc diffusion tests.

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Journal: Antimicrob Agents Chemother Date: 2001-10 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 2001-09 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1980-11 Impact factor: 5.191

7. In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.

Authors: Yigong Ge; Donald Biek; George H Talbot; Daniel F Sahm
Journal: Antimicrob Agents Chemother Date: 2008-07-14 Impact factor: 5.191

8. In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model.

Authors: Cédric Jacqueline; Jocelyne Caillon; Virginie Le Mabecque; Anne-Françoise Miègeville; Antoine Hamel; Denis Bugnon; James Yigong Ge; Gilles Potel
Journal: Antimicrob Agents Chemother Date: 2007-06-25 Impact factor: 5.191

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Journal: Clin Microbiol Rev Date: 1992-10 Impact factor: 26.132

10. Teicoplanin versus vancomycin for prophylaxis of experimental Enterococcus faecalis endocarditis in rats.

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Journal: Antimicrob Agents Chemother Date: 1992-06 Impact factor: 5.191

12 in total

Review 1. Ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.

Authors: Thomas P Lodise; Donald E Low
Journal: Drugs Date: 2012-07-30 Impact factor: 9.546

Review 2. Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci.

Authors: Sebastiano Leone; Silvana Noviello; Silvano Esposito
Journal: Infection Date: 2015-09-01 Impact factor: 3.553

Review 3. Ceftaroline fosamil: a review of its use in the treatment of complicated skin and soft tissue infections and community-acquired pneumonia.

Authors: James E Frampton
Journal: Drugs Date: 2013-07 Impact factor: 9.546

4. Ampicillin in Combination with Ceftaroline, Cefepime, or Ceftriaxone Demonstrates Equivalent Activities in a High-Inoculum Enterococcus faecalis Infection Model.

Authors: Megan K Luther; Louis B Rice; Kerry L LaPlante
Journal: Antimicrob Agents Chemother Date: 2016-04-22 Impact factor: 5.191