Literature DB >> 19752272

Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury.

Andrew J Dalley1, Renae Deans, Jeffrey Lipman, Bala Venkatesh, Michael Rudd, Michael S Roberts, Sheree E Cross.   

Abstract

Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% +/- 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%). Mean residence times and distribution volumes increased between 1 and 4 days posttrauma, suggesting that burn patient pharmacokinetics change during the initial fluid resuscitation phase of treatment.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19752272      PMCID： PMC2786355          DOI： 10.1128/AAC.01600-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods.

Authors:  A M Almeida; M M Castel-Branco; A C Falcão
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2002-07-15       Impact factor: 3.205

2.  Prediction of creatinine clearance from serum creatinine.

Authors:  D W Cockcroft; M H Gault
Journal:  Nephron       Date:  1976       Impact factor: 2.847

3.  Estimation of human body surface area from height and weight.

Authors:  E A Gehan; S L George
Journal:  Cancer Chemother Rep       Date:  1970-08

4.  APACHE II: a severity of disease classification system.

Authors:  W A Knaus; E A Draper; D P Wagner; J E Zimmerman
Journal:  Crit Care Med       Date:  1985-10       Impact factor: 7.598

Review 5.  Pharmacological principles of antibiotic prescription in the critically ill.

Authors:  M Pinder; R Bellomo; J Lipman
Journal:  Anaesth Intensive Care       Date:  2002-04       Impact factor: 1.669

Review 6.  Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis.

Authors:  Jason A Roberts; Jeffrey Lipman
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

7.  Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers.

Authors:  Andrew J Dalley; Jeffrey Lipman; Renae Deans; Bala Venkatesh; Michael Rudd; Michael S Roberts; Sheree E Cross
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191

8.  Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.

Authors:  John F Mohr; Luis Ostrosky-Zeichner; David J Wainright; Donald H Parks; Timothy C Hollenbeck; Charles D Ericsson
Journal:  Antimicrob Agents Chemother       Date:  2008-02-25       Impact factor: 5.191

Review 9.  Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients.

Authors:  Benoit Blanchet; Vincent Jullien; Christophe Vinsonneau; Michel Tod
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

10.  Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement.

Authors:  Andrew J Dalley; Jeffrey Lipman; Bala Venkatesh; Michael Rudd; Michael S Roberts; Sheree E Cross
Journal:  J Antimicrob Chemother       Date:  2007-05-15       Impact factor: 5.790
View more
  4 in total

Review 1.  The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients.

Authors:  Marta Ulldemolins; Jason A Roberts; Jordi Rello; David L Paterson; Jeffrey Lipman
Journal:  Clin Pharmacokinet       Date:  2011-02       Impact factor: 6.447

Review 2.  Impact of Changes in Free Concentrations and Drug-Protein Binding on Drug Dosing Regimens in Special Populations and Disease States.

Authors:  Marie N Celestin; Florin M Musteata
Journal:  J Pharm Sci       Date:  2021-06-02       Impact factor: 3.784

Review 3.  Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.

Authors:  Rui Pedro Veiga; José-Artur Paiva
Journal:  Crit Care       Date:  2018-09-24       Impact factor: 9.097

4.  Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses.

Authors:  Taisuke Kuroda; Yohei Minamijima; Hidekazu Niwa; Norihisa Tamura; Hiroshi Mita; Kentaro Fukuda; Masahiro Kaimachi; Yuto Suzuki; Yuki Enoki; Kazuaki Taguchi; Kazuaki Matsumoto; Pierre-Louis Toutain; Alain Bousquet-Melou; Yoshinori Kasashima
Journal:  Equine Vet J       Date:  2021-01-21       Impact factor: 2.888
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.