| Literature DB >> 18299410 |
John F Mohr1, Luis Ostrosky-Zeichner, David J Wainright, Donald H Parks, Timothy C Hollenbeck, Charles D Ericsson.
Abstract
Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.Entities:
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Year: 2008 PMID: 18299410 PMCID: PMC2346633 DOI: 10.1128/AAC.01321-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191