Literature DB >> 19748461

Shifting the paradigm: host gene signatures for diagnosis of infectious diseases.

Octavio Ramilo1, Asunción Mejías.   

Abstract

Instead of focusing on the pathogen, in a paradigm shift, Zaas et al. (2009) identified host gene profiles as a strategy for diagnosis of respiratory infections. Application of host gene profiles offers tremendous possibilities for identification of diagnostic signatures, markers of disease severity, and eventually, prognostic indicators in the clinical setting.

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Year:  2009        PMID： 19748461     DOI： 10.1016/j.chom.2009.08.007

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  19 in total

1.  The future possibilities of diagnostic testing for the evaluation of febrile infants.

Authors:  Prashant Mahajan; Octavio Ramilo; Nathan Kuppermann
Journal:  JAMA Pediatr       Date:  2013-10       Impact factor: 16.193

2.  Gene expression profiles in febrile children with defined viral and bacterial infection.

Authors:  Xinran Hu; Jinsheng Yu; Seth D Crosby; Gregory A Storch
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-15       Impact factor: 11.205

3.  Dynamic transcriptional signatures and network responses for clinical symptoms in influenza-infected human subjects using systems biology approaches.

Authors:  Patrice Linel; Shuang Wu; Nan Deng; Hulin Wu
Journal:  J Pharmacokinet Pharmacodyn       Date:  2014-10       Impact factor: 2.745

Review 4.  Detecting specific infections in children through host responses: a paradigm shift.

Authors:  Asuncion Mejias; Nicolas M Suarez; Octavio Ramilo
Journal:  Curr Opin Infect Dis       Date:  2014-06       Impact factor: 4.915

5.  Host Gene Expression in Nose and Blood for the Diagnosis of Viral Respiratory Infection.

Authors:  Jinsheng Yu; Derick R Peterson; Andrea M Baran; Soumyaroop Bhattacharya; Todd N Wylie; Ann R Falsey; Thomas J Mariani; Gregory A Storch
Journal:  J Infect Dis       Date:  2019-04-01       Impact factor: 5.226

Review 6.  Improving the Diagnosis, Management, and Outcomes of Children with Pneumonia: Where are the Gaps?

Authors:  Anne B Chang; Mong H Ooi; David Perera; Keith Grimwood
Journal:  Front Pediatr       Date:  2013-10-23       Impact factor: 3.418

7.  A novel host-proteome signature for distinguishing between acute bacterial and viral infections.

Authors:  Kfir Oved; Asi Cohen; Olga Boico; Roy Navon; Tom Friedman; Liat Etshtein; Or Kriger; Ellen Bamberger; Yura Fonar; Renata Yacobov; Ron Wolchinsky; Galit Denkberg; Yaniv Dotan; Amit Hochberg; Yoram Reiter; Moti Grupper; Isaac Srugo; Paul Feigin; Malka Gorfine; Irina Chistyakov; Ron Dagan; Adi Klein; Israel Potasman; Eran Eden
Journal:  PLoS One       Date:  2015-03-18       Impact factor: 3.240

8.  A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.

Authors:  Christopher W Woods; Micah T McClain; Minhua Chen; Aimee K Zaas; Bradly P Nicholson; Jay Varkey; Timothy Veldman; Stephen F Kingsmore; Yongsheng Huang; Robert Lambkin-Williams; Anthony G Gilbert; Alfred O Hero; Elizabeth Ramsburg; Seth Glickman; Joseph E Lucas; Lawrence Carin; Geoffrey S Ginsburg
Journal:  PLoS One       Date:  2013-01-09       Impact factor: 3.240

9.  The host response to infection: advancing a novel diagnostic paradigm.

Authors:  Geoffrey S Ginsburg; Christopher W Woods
Journal:  Crit Care       Date:  2012-11-06       Impact factor: 9.097

Review 10.  Host transcriptional signatures as predictive markers of infection in children.

Authors:  Asuncion Mejias; Shira Cohen; Rebecca Glowinski; Octavio Ramilo
Journal:  Curr Opin Infect Dis       Date:  2021-10-01       Impact factor: 4.968
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