Literature DB >> 19747561

Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.

Almudena Pacheco1, Jonathan Chernoff.   

Abstract

Group I p21-activated kinases are a highly conserved three-member family of serine/threonine kinases that act as key effectors for the small GTPases Cdc42 and Rac. In man, these enzymes have been implicated in a wide range of biological processes and are beginning to draw the attention of the pharmaceutical industry as potential therapeutic targets in cancer and in inflammatory processes. In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection.

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Year:  2009        PMID： 19747561      PMCID： PMC2787825          DOI： 10.1016/j.biocel.2009.09.006

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  21 in total

1.  HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.

Authors:  D Wolf; V Witte; B Laffert; K Blume; E Stromer; S Trapp; P d'Aloja; A Schürmann; A S Baur
Journal:  Nat Med       Date:  2001-11       Impact factor: 53.440

2.  Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV.

Authors:  Thomas Linnemann; Yong-Hui Zheng; Robert Mandic; B Matija Peterlin
Journal:  Virology       Date:  2002-03-15       Impact factor: 3.616

3.  Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.

Authors:  Céline Van den Broeke; Maria Radu; Matthias Deruelle; Hans Nauwynck; Clemens Hofmann; Zahara M Jaffer; Jonathan Chernoff; Herman W Favoreel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-12       Impact factor: 11.205

4.  p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Authors:  Jayme D Allen; Zahara M Jaffer; Su-Jung Park; Sarah Burgin; Clemens Hofmann; Mary Ann Sells; Shi Chen; Ethel Derr-Yellin; Elizabeth G Michels; Andrew McDaniel; Waylan K Bessler; David A Ingram; Simon J Atkinson; Jeffrey B Travers; Jonathan Chernoff; D Wade Clapp
Journal:  Blood       Date:  2009-01-05       Impact factor: 22.113

5.  PAK1 and PAK2 have different roles in HGF-induced morphological responses.

Authors:  Michael D Bright; Andrew P Garner; Anne J Ridley
Journal:  Cell Signal       Date:  2009-07-21       Impact factor: 4.315

6.  Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.

Authors:  Salvatore J Coniglio; Salvatore Zavarella; Marc H Symons
Journal:  Mol Cell Biol       Date:  2008-04-14       Impact factor: 4.272

7.  Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells.

Authors:  Jason Mercer; Ari Helenius
Journal:  Science       Date:  2008-04-25       Impact factor: 47.728

Review 8.  PAK signalling in neuronal physiology.

Authors:  Patricia Kreis; Jean-Vianney Barnier
Journal:  Cell Signal       Date:  2008-11-12       Impact factor: 4.315

Review 9.  Pak protein kinases and their role in cancer.

Authors:  Bettina Dummler; Kazufumi Ohshiro; Rakesh Kumar; Jeffrey Field
Journal:  Cancer Metastasis Rev       Date:  2009-06       Impact factor: 9.264

10.  Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.

Authors:  Christine M Lightcap; Gabor Kari; Luis E Arias-Romero; Jonathan Chernoff; Ulrich Rodeck; John C Williams
Journal:  PLoS One       Date:  2009-06-26       Impact factor: 3.240
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  11 in total

Review 1.  PAK1 as a therapeutic target.

Authors:  Julia V Kichina; Anna Goc; Belal Al-Husein; Payaningal R Somanath; Eugene S Kandel
Journal:  Expert Opin Ther Targets       Date:  2010-07       Impact factor: 6.902

2.  Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase.

Authors:  C Van den Broeke; M Radu; H J Nauwynck; J Chernoff; H W Favoreel
Journal:  Virus Res       Date:  2010-11-18       Impact factor: 3.303

Review 3.  P21-activated kinase in inflammatory and cardiovascular disease.

Authors:  Domenico M Taglieri; Masuko Ushio-Fukai; Michelle M Monasky
Journal:  Cell Signal       Date:  2014-05-02       Impact factor: 4.315

4.  p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.

Authors:  Xiaohua Yan; Junyu Zhang; Qinyu Sun; Polygena T Tuazon; Xiaoping Wu; Jolinda A Traugh; Ye-Guang Chen
Journal:  J Biol Chem       Date:  2012-03-05       Impact factor: 5.157

5.  Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway.

Authors:  W Zhang; H Liu; W Liu; Y Liu; J Xu
Journal:  Cell Death Differ       Date:  2014-09-12       Impact factor: 15.828

6.  Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.

Authors:  K Grauwet; M Vitale; S De Pelsmaeker; T Jacob; K Laval; L Moretta; M Parodi; S Parolini; C Cantoni; H W Favoreel
Journal:  J Virol       Date:  2015-11-18       Impact factor: 5.103

Review 7.  The suppression of apoptosis by α-herpesvirus.

Authors:  Yu You; An-Chun Cheng; Ming-Shu Wang; Ren-Yong Jia; Kun-Feng Sun; Qiao Yang; Ying Wu; Dekang Zhu; Shun Chen; Ma-Feng Liu; Xin-Xin Zhao; Xiao-Yue Chen
Journal:  Cell Death Dis       Date:  2017-04-13       Impact factor: 8.469

8.  Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.

Authors:  Wyn C Hoover; Wenwu Zhang; Zhidong Xue; Huanling Gao; Jonathan Chernoff; D Wade Clapp; Susan J Gunst; Robert S Tepper
Journal:  PLoS One       Date:  2012-08-10       Impact factor: 3.240

Review 9.  Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.

Authors:  Simona John Von Freyend; Terry Kwok-Schuelein; Hans J Netter; Gholamreza Haqshenas; Jean-Philippe Semblat; Christian Doerig
Journal:  Pathogens       Date:  2017-04-21

10.  Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction.

Authors:  Wanli Ma; Xiaohe Wang; Chunhui Wang; Mingzhi Gong; Peng Ren
Journal:  Biosci Rep       Date:  2020-01-31       Impact factor: 3.840
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