Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells.

Literature DB >> 18436786

Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells.

Abstract

Viruses employ many different strategies to enter host cells. Vaccinia virus, a prototype poxvirus, enters cells in a pH-dependent fashion. Live cell imaging showed that fluorescent virus particles associated with and moved along filopodia to the cell body, where they were internalized after inducing the extrusion of large transient membrane blebs. p21-activated kinase 1 (PAK1) was activated by the virus, and the endocytic process had the general characteristics of macropinocytosis. The induction of blebs, the endocytic event, and infection were all critically dependent on the presence of exposed phosphatidylserine in the viral membrane, which suggests that vaccinia virus uses apoptotic mimicry to enter cells.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18436786 DOI： 10.1126/science.1155164

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

377 in total

1. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides.

Authors: Zhenping Wang; Yuping Lai; Jamie J Bernard; Daniel T Macleod; Anna L Cogen; Bernard Moss; Anna Di Nardo
Journal: J Immunol Date: 2011-12-02 Impact factor: 5.422

2. Vaccinia virus A25 and A26 proteins are fusion suppressors for mature virions and determine strain-specific virus entry pathways into HeLa, CHO-K1, and L cells.

Authors: Shu-Jung Chang; Yu-Xun Chang; Roza Izmailyan; Yin-Liang Tang; Wen Chang
Journal: J Virol Date: 2010-06-10 Impact factor: 5.103

3. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential.

Authors: Michael Zasloff; A Paige Adams; Bernard Beckerman; Ann Campbell; Ziying Han; Erik Luijten; Isaura Meza; Justin Julander; Abhijit Mishra; Wei Qu; John M Taylor; Scott C Weaver; Gerard C L Wong
Journal: Proc Natl Acad Sci U S A Date: 2011-09-19 Impact factor: 11.205

4. Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.

Authors: Rostyslav O Bilyy; Tanya Shkandina; Andriy Tomin; Luis E Muñoz; Sandra Franz; Volodymyr Antonyuk; Yuriy Ya Kit; Matthias Zirngibl; Barbara G Fürnrohr; Christina Janko; Kirsten Lauber; Martin Schiller; Georg Schett; Rostyslav S Stoika; Martin Herrmann
Journal: J Biol Chem Date: 2011-11-10 Impact factor: 5.157

Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells.

1. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides.

2. Vaccinia virus A25 and A26 proteins are fusion suppressors for mature virions and determine strain-specific virus entry pathways into HeLa, CHO-K1, and L cells.

3. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential.

4. Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.

5. Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration.

6. Viral infection: Moving through complex and dynamic cell-membrane structures.

Review 7. The role of actin bundling proteins in the assembly of filopodia in epithelial cells.

8. Blebbing confers resistance against cell lysis.

Review 9. Exploitation of Cytoskeletal Networks during Early Viral Infection.

10. Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.