Literature DB >> 19741262

New paradigms in the pathogenesis of chronic obstructive pulmonary disease I.

William MacNee1, Rubin M Tuder.   

Abstract

This paper reviews the potential participation of novel pathogenic mechanisms in chronic obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and enhanced expression of markers of senescence in emphysematous lungs and the potential enhanced tissue destruction involving alveolar apoptosis. These insights provide new beginnings for future investigations in the pathobiology of COPD which may lead to future therapies for this condition.

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Year:  2009        PMID： 19741262     DOI： 10.1513/pats.200905-027DS

Source DB:  PubMed          Journal:  Proc Am Thorac Soc        ISSN： 1546-3222


  45 in total

Review 1.  Regulation of SIRT1 in cellular functions: role of polyphenols.

Authors:  Sangwoon Chung; Hongwei Yao; Samuel Caito; Jae-Woong Hwang; Gnanapragasam Arunachalam; Irfan Rahman
Journal:  Arch Biochem Biophys       Date:  2010-05-05       Impact factor: 4.013

Review 2.  Stress responses affecting homeostasis of the alveolar capillary unit.

Authors:  Rubin M Tuder; Toshinori Yoshida
Journal:  Proc Am Thorac Soc       Date:  2011-11

Review 3.  Lung disease associated with alpha1-antitrypsin deficiency.

Authors:  Rubin M Tuder; Sabina M Janciauskiene; Irina Petrache
Journal:  Proc Am Thorac Soc       Date:  2010-11

Review 4.  The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases.

Authors:  Luca Antonioli; Corrado Blandizzi; Pál Pacher; György Haskó
Journal:  Pharmacol Rev       Date:  2019-07       Impact factor: 25.468

Review 5.  Senescence in chronic obstructive pulmonary disease.

Authors:  Rubin M Tuder; Jeffrey A Kern; York E Miller
Journal:  Proc Am Thorac Soc       Date:  2012-05

6.  Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers.

Authors:  W M Chatila; G J Criner; W W Hancock; T Akimova; B Moldover; J-K Chang; W Cornwell; M Santerre; T J Rogers
Journal:  Clin Exp Immunol       Date:  2014-07       Impact factor: 4.330

7.  Emphysema classification based on embedded probabilistic PCA.

Authors:  Teresa Zulueta-Coarasa; Sila Kurugol; James C Ross; George G Washko; Raúl San José Estépar
Journal:  Conf Proc IEEE Eng Med Biol Soc       Date:  2013

8.  Involvement of B-cell CLL/lymphoma 2 promoter methylation in cigarette smoke extract-induced emphysema.

Authors:  Huihui Zeng; Zhihui Shi; Xianglong Kong; Yan Chen; Hongliang Zhang; Hong Peng; Hong Luo; Ping Chen
Journal:  Exp Biol Med (Maywood)       Date:  2016-02-27

Review 9.  Blocking NF-κB: an inflammatory issue.

Authors:  Arshad Rahman; Fabeha Fazal
Journal:  Proc Am Thorac Soc       Date:  2011-11

Review 10.  Influencing the decline of lung function in COPD: use of pharmacotherapy.

Authors:  Ekaterina S Gladysheva; Atul Malhotra; Robert L Owens
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2010-06-03
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