| Literature DB >> 19740503 |
Matthew Cairns1, Roly Gosling, Samwel Gesase, Jacklin Mosha, Brian Greenwood, Daniel Chandramohan.
Abstract
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective drug for IPTi. Work recently conducted in Tanzania, combined with the findings of previous studies, indicates that IPTi is essentially intermittent chemoprophylaxis; consequently, long-acting antimalarials that provide a long period of post-treatment prophylaxis will be the most effective alternative to SP. However, because of concerns about development of drug resistance, new combinations of long-acting drugs are urgently needed.Entities:
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Year: 2009 PMID： 19740503 PMCID： PMC3787296 DOI： 10.1016/j.trstmh.2009.06.007
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184