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Literature DB >> 19736468

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.

Ahmed Ragheb¹, Ahmed Attia, Walid Shehab Eldin, Fawzy Elbarbry, Sana Gazarin, Ahmed Shoker.

Abstract

Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti-oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.

Entities: Chemical Disease Species

Mesh：

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Year: 2009 PMID： 19736468

Source DB: PubMed Journal: Saudi J Kidney Dis Transpl ISSN： 1319-2442

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Cited

39 in total

1. Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice.

Authors: Xiaofei Lei; Meng Liu; Zirong Yang; Mengyao Ji; Xufeng Guo; Weiguo Dong
Journal: Dig Dis Sci Date: 2012-04-03 Impact factor: 3.199

2. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors: Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal: Curr Drug Targets Date: 2011-10 Impact factor: 3.465

9. Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects.

Authors: Ali Parlar; Seyfullah Oktay Arslan
Journal: Turk J Surg Date: 2020-03-18

10. Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling.

Authors: Gamal Badr; Mohamed H Mahmoud; Karim Farhat; Hanan Waly; Osman Zin Al-Abdin; Danny M Rabah
Journal: Lipids Health Dis Date: 2013-03-18 Impact factor: 3.876

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.

1. Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice.

2. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

3. Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model.

4. The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats.

5. Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery.

Review 6. Anticancer activities of Nigella sativa (black cumin).

7. The Effect of the Active Ingredient Thymoquinone on Flap Viability in Random Pattern Flaps in Rats.

8. Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats.

9. Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects.

10. Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling.