| Literature DB >> 19736007 |
Guo-Hua Chu1, Christopher T Saeui, Karin Worm, Damian G Weaver, Allan J Goodman, Robert L Broadrup, Joel A Cassel, Robert N DeHaven, Christopher J LaBuda, Michael Koblish, Bernice Brogdon, Steve Smith, Bertrand Le Bourdonnec, Roland E Dolle.
Abstract
Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.Entities:
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Year: 2009 PMID： 19736007 DOI： 10.1016/j.bmcl.2009.08.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823