Spectrofluorimetric assessment of Ramipril using optical sensor Samarium ion-doxycycline complex doped in sol-gel matrix.

A new, simple, sensitive and selective spectrofluorimetric method for the determination of Ramipril is developed. The Ramipril can remarkably quench the luminescence intensity of the Sm(3+) ion in Sm(3+)-doxycycline complex at lambda(ex)=375 nm in sol-gel matrix. In the same time the intensity of the emission band of the Ramipril in DMSO at 454 nm is increased due to the energy transfer from the Sm(3+)-doxycycline complex to Ramipril in the excited stated. The quenching of luminescence intensity of Sm(3+)-doxycycline complex doped in the sol-gel matrix and the enhancement of the emission band of Ramipril at 454 nm are directly proportion to the concentration of Ramipril with a dynamic ranges of 3.4x10(-9) - 1.0x10(-7)mol l(-1) and 2.4x10(-9) - 1.0x10(-7)mol l(-1) and detection limits of 6.0x10(-10) and 5.2x10(-10)mol l(-1), respectively.