Literature DB >> 19733530

Growth signaling at the nexus of stem cell life and death.

Kris C Wood1, David M Sabatini.   

Abstract

Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively.

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Year:  2009        PMID： 19733530      PMCID： PMC3390250          DOI： 10.1016/j.stem.2009.08.008

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  11 in total

1.  Rejuvenation of aged progenitor cells by exposure to a young systemic environment.

Authors:  Irina M Conboy; Michael J Conboy; Amy J Wagers; Eric R Girma; Irving L Weissman; Thomas A Rando
Journal:  Nature       Date:  2005-02-17       Impact factor: 49.962

2.  Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Authors:  Viktor Janzen; Randolf Forkert; Heather E Fleming; Yoriko Saito; Michael T Waring; David M Dombkowski; Tao Cheng; Ronald A DePinho; Norman E Sharpless; David T Scadden
Journal:  Nature       Date:  2006-09-06       Impact factor: 49.962

Review 3.  Stems cells and the pathways to aging and cancer.

Authors:  Derrick J Rossi; Catriona H M Jamieson; Irving L Weissman
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

4.  Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.

Authors:  Ken Inomata; Takahiro Aoto; Nguyen Thanh Binh; Natsuko Okamoto; Shintaro Tanimura; Tomohiko Wakayama; Shoichi Iseki; Eiji Hara; Takuji Masunaga; Hiroshi Shimizu; Emi K Nishimura
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

5.  p16INK4a induces an age-dependent decline in islet regenerative potential.

Authors:  Janakiraman Krishnamurthy; Matthew R Ramsey; Keith L Ligon; Chad Torrice; Angela Koh; Susan Bonner-Weir; Norman E Sharpless
Journal:  Nature       Date:  2006-09-06       Impact factor: 49.962

6.  Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.

Authors:  Anna V Molofsky; Shalom G Slutsky; Nancy M Joseph; Shenghui He; Ricardo Pardal; Janakiraman Krishnamurthy; Norman E Sharpless; Sean J Morrison
Journal:  Nature       Date:  2006-09-06       Impact factor: 49.962

7.  Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Authors:  Omer H Yilmaz; Riccardo Valdez; Brian K Theisen; Wei Guo; David O Ferguson; Hong Wu; Sean J Morrison
Journal:  Nature       Date:  2006-04-05       Impact factor: 49.962

Review 8.  Mitochondrial signaling, TOR, and life span.

Authors:  Stefan M Schieke; Toren Finkel
Journal:  Biol Chem       Date:  2006 Oct-Nov       Impact factor: 3.915

9.  mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

Authors:  Rogerio M Castilho; Cristiane H Squarize; Lewis A Chodosh; Bart O Williams; J Silvio Gutkind
Journal:  Cell Stem Cell       Date:  2009-09-04       Impact factor: 24.633

10.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Authors:  David E Harrison; Randy Strong; Zelton Dave Sharp; James F Nelson; Clinton M Astle; Kevin Flurkey; Nancy L Nadon; J Erby Wilkinson; Krystyna Frenkel; Christy S Carter; Marco Pahor; Martin A Javors; Elizabeth Fernandez; Richard A Miller
Journal:  Nature       Date:  2009-07-08       Impact factor: 49.962
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  4 in total

Review 1.  Brain response to calorie restriction.

Authors:  Salvatore Fusco; Giovambattista Pani
Journal:  Cell Mol Life Sci       Date:  2012-12-27       Impact factor: 9.261

2.  Adult Stem Cells and Diseases of Aging.

Authors:  Lisa B Boyette; Rocky S Tuan
Journal:  J Clin Med       Date:  2014-01-21       Impact factor: 4.241

3.  Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging.

Authors:  Jing Li; Dachuan Cai; Xin Yao; Yanyan Zhang; Linbo Chen; Pengwei Jing; Lu Wang; Yaping Wang
Journal:  Int J Mol Sci       Date:  2016-06-09       Impact factor: 5.923

Review 4.  Lifetime Impact of Cow's Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration.

Authors:  Bodo C Melnik
Journal:  Biomolecules       Date:  2021-03-09
  4 in total

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