OBJECTIVE: The purpose of this study was to evaluate combined fetal fibronectin (fFN) test result and cervical length (CL) as predictors of spontaneous preterm birth in asymptomatic twin pregnancies. STUDY DESIGN: We examined a retrospective cohort of 155 twin pregnancies with combined fFN and CL testing between 22 and 32 weeks gestation. RESULTS: A positive fFN test result at 22-32 weeks or a CL <20 mm increased the risk of spontaneous preterm birth at <37, <34, <32, <30, and <28 weeks' gestation. The combination of a positive fFN test result and CL<20 mm had a significantly higher positive predictive value for delivery at all gestational ages than either positive test alone. On adjusted analysis, a positive fFN test result was a stronger predictor of spontaneous preterm birth than a short CL. CONCLUSION: In asymptomatic twin pregnancies, fFN and CL testing between 22 and 32 weeks gestation can identify pregnancies that are at significantly increased risk for preterm birth, including deliveries at <28 weeks' gestation.
OBJECTIVE: The purpose of this study was to evaluate combined fetal fibronectin (fFN) test result and cervical length (CL) as predictors of spontaneous preterm birth in asymptomatic twin pregnancies. STUDY DESIGN: We examined a retrospective cohort of 155 twin pregnancies with combined fFN and CL testing between 22 and 32 weeks gestation. RESULTS: A positive fFN test result at 22-32 weeks or a CL <20 mm increased the risk of spontaneous preterm birth at <37, <34, <32, <30, and <28 weeks' gestation. The combination of a positive fFN test result and CL<20 mm had a significantly higher positive predictive value for delivery at all gestational ages than either positive test alone. On adjusted analysis, a positive fFN test result was a stronger predictor of spontaneous preterm birth than a short CL. CONCLUSION: In asymptomatic twin pregnancies, fFN and CL testing between 22 and 32 weeks gestation can identify pregnancies that are at significantly increased risk for preterm birth, including deliveries at <28 weeks' gestation.
Authors: Agustin Conde-Agudelo; Roberto Romero; Eduardo Da Fonseca; John M O'Brien; Elcin Cetingoz; George W Creasy; Sonia S Hassan; Offer Erez; Percy Pacora; Kypros H Nicolaides Journal: Am J Obstet Gynecol Date: 2018-04-07 Impact factor: 8.661
Authors: Roberto Romero; Agustin Conde-Agudelo; Eduardo Da Fonseca; John M O'Brien; Elcin Cetingoz; George W Creasy; Sonia S Hassan; Kypros H Nicolaides Journal: Am J Obstet Gynecol Date: 2017-11-17 Impact factor: 8.661