BACKGROUND: Cystic fibrosis-associated liver disease (CFLD) is the second cause of mortality in CF. The prevalence is estimated to be 26-45%, but sensitive diagnostic tools are lacking. We investigated whether non-invasive liver elastography (Fibroscan) could serve as a screening tool. METHODS: Fibroscan measurements were performed in 66 CF patients. Age-specific cutoff values were determined in a control population (n=59). The measurements were compared to clinical data, bi-yearly biochemistry and ultrasound. RESULTS: Fibroscan was easy to perform in this patient population. There were 14 patients (21%) with abnormal liver stiffness measurements. Liver stiffness was significantly increased in patients with clinical CFLD (11.2 kPa versus 5.1 kPa), biochemical CFLD (7.4 kPa versus 5.4 kPa) or ultrasonographical CFLD (8.2 versus 4.3 kPa) (p<0.02 for all). CONCLUSIONS: Fibroscan is an objective measure and is easy to perform in CF patients, even in children and could provide a valuable tool to detect, and quantify CFLD.
BACKGROUND: Cystic fibrosis-associated liver disease (CFLD) is the second cause of mortality in CF. The prevalence is estimated to be 26-45%, but sensitive diagnostic tools are lacking. We investigated whether non-invasive liver elastography (Fibroscan) could serve as a screening tool. METHODS: Fibroscan measurements were performed in 66 CFpatients. Age-specific cutoff values were determined in a control population (n=59). The measurements were compared to clinical data, bi-yearly biochemistry and ultrasound. RESULTS: Fibroscan was easy to perform in this patient population. There were 14 patients (21%) with abnormal liver stiffness measurements. Liver stiffness was significantly increased in patients with clinical CFLD (11.2 kPa versus 5.1 kPa), biochemical CFLD (7.4 kPa versus 5.4 kPa) or ultrasonographical CFLD (8.2 versus 4.3 kPa) (p<0.02 for all). CONCLUSIONS: Fibroscan is an objective measure and is easy to perform in CFpatients, even in children and could provide a valuable tool to detect, and quantify CFLD.
Authors: Christopher Koh; Sasan Sakiani; Pallavi Surana; Xiongce Zhao; Jason Eccleston; David E Kleiner; David Herion; T Jake Liang; Jay H Hoofnagle; Milica Chernick; Theo Heller Journal: Hepatology Date: 2017-06-26 Impact factor: 17.425
Authors: Jack X Q Pang; Faruq Pradhan; Scott Zimmer; Sophia Niu; Pam Crotty; Jenna Tracey; Christopher Schneider; Steven J Heitman; Gilaad G Kaplan; Mark G Swain; Robert P Myers Journal: Can J Gastroenterol Hepatol Date: 2014-03
Authors: L Monti; M Manco; C Lo Zupone; A Latini; M L D'Andrea; F Alghisi; V Lucidi; P Tomà; L Bonomo Journal: Radiol Med Date: 2012-09-17 Impact factor: 3.469
Authors: Thomas Karlas; Marie Neuschulz; Annett Oltmanns; Andrea Güttler; David Petroff; Hubert Wirtz; Jochen G Mainz; Joachim Mössner; Thomas Berg; Michael Tröltzsch; Volker Keim; Johannes Wiegand Journal: PLoS One Date: 2012-07-25 Impact factor: 3.240