Lucija Ruzman1, Ivana Mikolasevic2, Kristina Baraba Dekanic3, Sandra Milic2, Goran Palcevski3. 1. Pediatric Clinic, UHC Rijeka, Istarska 43, 51 000, Rijeka, Croatia. lucija.ruzman@gmail.com. 2. Department of Gastroenterology, UHC Rijeka, Rijeka, Croatia. 3. Pediatric Clinic, Department of Gastroenterology, UHC Rijeka, Rijeka, Croatia.
Abstract
BACKGROUND: Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recognition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available. METHODS: A non-systematic literature search was performed to summarize the current knowledge about transient elastography (TE) with controlled attenuation parameter (CAP) in children with CLD. Ovid MEDLINE, Ovid EMBASE, Google scholar, and The Cochrane Library databases were searched for relevant articles evaluating TE in the pediatric population. RESULTS: Normal values of liver stiffness measurements (LSM) according to the age are given, as well as the advantages and disadvantages of the method. The utility of TE in specific liver disease in pediatric population is summarized. CONCLUSIONS: TE with CAP is a valuable non-invasive method for the liver-damage assessment. Clinical interpretation of TE results should be made in parallel with the assessment of the patient's demographics, disease etiology, and essential laboratory parameters.
BACKGROUND:Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recognition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available. METHODS: A non-systematic literature search was performed to summarize the current knowledge about transient elastography (TE) with controlled attenuation parameter (CAP) in children with CLD. Ovid MEDLINE, Ovid EMBASE, Google scholar, and The Cochrane Library databases were searched for relevant articles evaluating TE in the pediatric population. RESULTS: Normal values of liver stiffness measurements (LSM) according to the age are given, as well as the advantages and disadvantages of the method. The utility of TE in specific liver disease in pediatric population is summarized. CONCLUSIONS: TE with CAP is a valuable non-invasive method for the liver-damage assessment. Clinical interpretation of TE results should be made in parallel with the assessment of the patient's demographics, disease etiology, and essential laboratory parameters.
Authors: Eyal Shteyer; Grant A Ramm; Chunxia Xu; Frances V White; Ross W Shepherd Journal: J Pediatr Gastroenterol Nutr Date: 2006-01 Impact factor: 2.839
Authors: Amal Aqul; Maureen M Jonas; Sarah Harney; Roshan Raza; Gregory S Sawicki; Paul D Mitchell; Rima Fawaz Journal: J Pediatr Gastroenterol Nutr Date: 2017-04 Impact factor: 2.839