Literature DB >> 19732031

New strategies to deliver anticancer drugs to brain tumors.

Valentino Laquintana1, Adriana Trapani, Nunzio Denora, Fan Wang, James M Gallo, Giuseppe Trapani.   

Abstract

BACKGROUND: Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineoplastic agents across the blood-brain barrier (BBB).
OBJECTIVE: The objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors.
METHODS: Both preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers.
CONCLUSION: Analysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19732031      PMCID： PMC2752842          DOI： 10.1517/17425240903167942

Source DB:  PubMed          Journal:  Expert Opin Drug Deliv        ISSN： 1742-5247            Impact factor:   6.648


  104 in total

Review 1.  The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery.

Authors:  D R Groothuis
Journal:  Neuro Oncol       Date:  2000-01       Impact factor: 12.300

2.  Vector-mediated drug delivery to the brain.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1999-04-05       Impact factor: 15.470

3.  Targeting cancer stem cells through L1CAM suppresses glioma growth.

Authors:  Shideng Bao; Qiulian Wu; Zhizhong Li; Sith Sathornsumetee; Hui Wang; Roger E McLendon; Anita B Hjelmeland; Jeremy N Rich
Journal:  Cancer Res       Date:  2008-08-01       Impact factor: 12.701

Review 4.  Blood-brain barrier and chemotherapeutic treatment of brain tumors.

Authors:  Nienke A de Vries; Jos H Beijnen; Willem Boogerd; Olaf van Tellingen
Journal:  Expert Rev Neurother       Date:  2006-08       Impact factor: 4.618

Review 5.  Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells.

Authors:  Ying Huang; Wolfgang Sadée
Journal:  Cancer Lett       Date:  2005-10-05       Impact factor: 8.679

Review 6.  Barriers to carrier mediated drug and gene delivery to brain tumors.

Authors:  Grace H Huynh; Dennis F Deen; Francis C Szoka
Journal:  J Control Release       Date:  2005-11-28       Impact factor: 9.776

Review 7.  Active targeting of brain tumors using nanocarriers.

Authors:  Arnaud Béduneau; Patrick Saulnier; Jean-Pierre Benoit
Journal:  Biomaterials       Date:  2007-08-22       Impact factor: 12.479

Review 8.  Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles.

Authors:  Ho Lun Wong; Reina Bendayan; Andrew M Rauth; Yongqiang Li; Xiao Yu Wu
Journal:  Adv Drug Deliv Rev       Date:  2007-05-01       Impact factor: 15.470

9.  Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide.

Authors:  Qingyu Zhou; Ping Guo; James M Gallo
Journal:  Clin Cancer Res       Date:  2008-03-01       Impact factor: 12.531

10.  TMZ-BioShuttle--a reformulated temozolomide.

Authors:  Waldemar Waldeck; Manfred Wiessler; Volker Ehemann; Ruediger Pipkorn; Herbert Spring; Juergen Debus; Bernd Didinger; Gabriele Mueller; Joerg Langowski; Klaus Braun
Journal:  Int J Med Sci       Date:  2008-09-15       Impact factor: 3.738
View more
  60 in total

1.  Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells.

Authors:  Gisela Natalia Castro; Niubys Cayado-Gutiérrez; Felipe Carlos Martín Zoppino; Mariel Andrea Fanelli; Fernando Darío Cuello-Carrión; Mayra Sottile; Silvina Beatriz Nadin; Daniel Ramón Ciocca
Journal:  Cell Stress Chaperones       Date:  2014-08-26       Impact factor: 3.667

2.  Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas.

Authors:  Wanlu Du; Ivan Seah; Oumaima Bougazzoul; GiHun Choi; Katrina Meeth; Marcus W Bosenberg; Hiroaki Wakimoto; David Fisher; Khalid Shah
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-14       Impact factor: 11.205

3.  Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors.

Authors:  Adriana Trapani; Nunzio Denora; Giuliano Iacobellis; Johannes Sitterberg; Udo Bakowsky; Thomas Kissel
Journal:  AAPS PharmSciTech       Date:  2011-09-27       Impact factor: 3.246

4.  Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-Cancer Potential and Improved In vivo Brain Pharmacokinetics of Temozolomide.

Authors:  Ashok Kumar Sharma; Lokesh Gupta; Hitesh Sahu; Arem Qayum; Shashank K Singh; Kartik T Nakhate; Umesh Gupta
Journal:  Pharm Res       Date:  2018-01-02       Impact factor: 4.200

5.  Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result.

Authors:  Andrea Orthmann; Reiner Zeisig; Regine Süss; Dorothea Lorenz; Margit Lemm; Iduna Fichtner
Journal:  Pharm Res       Date:  2012-03-08       Impact factor: 4.200

6.  Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas.

Authors:  Amanda R King; Christopher D Corso; Evan M Chen; Eric Song; Paul Bongiorni; Zhe Chen; Ranjini K Sundaram; Ranjit S Bindra; W Mark Saltzman
Journal:  Mol Cancer Ther       Date:  2017-05-31       Impact factor: 6.261

7.  Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models.

Authors:  Jinwei Hu; Julia Y Ljubimova; Satoshi Inoue; Bindu Konda; Rameshwar Patil; Hui Ding; Andres Espinoza; Kolja A Wawrowsky; Chirag Patil; Alexander V Ljubimov; Keith L Black
Journal:  PLoS One       Date:  2010-04-19       Impact factor: 3.240

8.  Nano to micro delivery systems: targeting angiogenesis in brain tumors.

Authors:  Ariel Gilert; Marcelle Machluf
Journal:  J Angiogenes Res       Date:  2010-10-08

9.  Mesenchymal migration as a therapeutic target in glioblastoma.

Authors:  Jessie Zhong; Andre Paul; Stewart J Kellie; Geraldine M O'Neill
Journal:  J Oncol       Date:  2010-06-21       Impact factor: 4.375

Review 10.  Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors: The Inspiration of Nanobiotechnology.

Authors:  Jianing Meng; Vivek Agrahari; Ibrahima Youm
Journal:  J Neuroimmune Pharmacol       Date:  2016-07-23       Impact factor: 4.147
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.